Universität zu Köln

Pauls, K. Amande M., Hammesfahr, Sven, Moro, Elena, Moore, A. Peter, Binder, Ellen, El Majdoub, Faycal, Fink, Gereon R. ORCID: 0000-0002-8230-1856, Sturm, Volker, Krauss, Joachim K., Maarouf, Mohammad and Timmermann, Lars (2014). Deep Brain Stimulation in the Ventrolateral Thalamus/Subthalamic Area in Dystonia With Head Tremor. Mov. Disord., 29 (7). S. 953 - 960. HOBOKEN: WILEY. ISSN 1531-8257

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Abstract

Background: Pallidal deep brain stimulation (GPi-DBS) effectively ameliorates idiopathic dystonia, although approximately 15% of patients respond insufficiently. Although various thalamic and subthalamic targets have been suggested for dystonic tremor, no systematic studies have been published on thalamic DBS in dystonic tremor. We assessed the effect of thalamic/subthalamic area DBS (Th-DBS) on dystonic head tremor and dystonia in a single-blind design. Methods: Dystonic head tremor and dystonia before and 3 months after surgery were quantified via blinded video-ratings using the Fahn-Tolosa-Marin-Tremor-Scale and the Burke-Fahn-Marsden-Dystonia-Rating-Scale in seven patients with idiopathic cervical or segmental dystonia, dystonic head tremor, and bilateral Th-DBS. Pain, side effects, adverse events, and stimulation parameters were assessed. Results: Th-DBS improved dystonic tremor and dystonia (P < 0.05; 57.1% and 70.4%, respectively). Head tremor amplitude and pain were also improved (P < 0.05; 77.5% and 90.0%, respectively). Side effects included dysarthria, gait disturbance, slowness of movement, and weight gain. Conclusion: Dystonic head tremor and dystonia can be improved with Th-DBS. (C) 2014 International Parkinson and Movement Disorder Society

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Pauls, K. Amande M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Hammesfahr, Sven UNSPECIFIED UNSPECIFIED UNSPECIFIED Moro, Elena UNSPECIFIED UNSPECIFIED UNSPECIFIED Moore, A. Peter UNSPECIFIED UNSPECIFIED UNSPECIFIED Binder, Ellen UNSPECIFIED UNSPECIFIED UNSPECIFIED El Majdoub, Faycal UNSPECIFIED UNSPECIFIED UNSPECIFIED Fink, Gereon R. UNSPECIFIED orcid.org/0000-0002-8230-1856 UNSPECIFIED Sturm, Volker UNSPECIFIED UNSPECIFIED UNSPECIFIED Krauss, Joachim K. UNSPECIFIED UNSPECIFIED UNSPECIFIED Maarouf, Mohammad UNSPECIFIED UNSPECIFIED UNSPECIFIED Timmermann, Lars UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-436784
DOI:	10.1002/mds.25884
Journal or Publication Title:	Mov. Disord.
Volume:	29
Number:	7
Page Range:	S. 953 - 960
Date:	2014
Publisher:	WILEY
Place of Publication:	HOBOKEN
ISSN:	1531-8257
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language POSTERIOR SUBTHALAMIC AREA; CERVICAL DYSTONIA; GLOBUS-PALLIDUS; BILATERAL STIMULATION; THALAMIC-STIMULATION; SUPPRESSION; MULTICENTER; NUCLEUS; DBS Multiple languages Clinical Neurology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/43678