Universität zu Köln

von Tresckow, Bastian and Diehl, Volker (2014). An update on emerging drugs for Hodgkin lymphoma. Expert Opin Emerg. Drugs, 19 (2). S. 215 - 225. ABINGDON: TAYLOR & FRANCIS LTD. ISSN 1744-7623

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Abstract

Introduction: Most patients with Hodgkin lymphoma (HL) are cured with modern combined modality first-line treatments. Even similar to 50% of patients with relapsed/refractory HL can be cured with high-dose chemotherapy (HDCT) and autologous stem cell transplantation. However, chemotherapy and radiotherapy cause significant acute and long-term side effects and patients relapsing after HDCT have a dismal prognosis. New drugs are therefore needed to reduce the toxicity of first-line treatments and to increase the efficacy of relapse treatments. Moreover, new drugs are needed for the treatment of older patients with HL because results with current treatments are disappointing. Areas covered: This article discusses promising new drugs for the treatment of classical HL that have been evaluated in the last years. There is a focus on the antibody drug conjugate brentuximab vedotin and its potential for the future treatment of HL. Moreover, data on the histone deacetylase inhibitors panobinostat and mocetinostat, the mammalian target of rapamycin inhibitor everolimus, the Janus kinase 2 inhibitor SB1518 and the immunomodulatory agent lenalidomide are summarized. Expert opinion: Besides improving the prognosis of relapsed patients, new drugs should be used to replace the most toxic compounds in first-line therapy to reduce acute and long-term toxicities of the treatment.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code von Tresckow, Bastian UNSPECIFIED UNSPECIFIED UNSPECIFIED Diehl, Volker UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-437029
DOI:	10.1517/14728214.2014.912277
Journal or Publication Title:	Expert Opin Emerg. Drugs
Volume:	19
Number:	2
Page Range:	S. 215 - 225
Date:	2014
Publisher:	TAYLOR & FRANCIS LTD
Place of Publication:	ABINGDON
ISSN:	1744-7623
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language STEM-CELL TRANSPLANTATION; BRENTUXIMAB VEDOTIN; OPEN-LABEL; PHASE-II; INTENSITY; EVEROLIMUS; TRIAL; LENALIDOMIDE; PANOBINOSTAT; INHIBITOR Multiple languages Pharmacology & Pharmacy Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/43702