Rovida, Costanza, Vivier, Manon, Garthoff, Bernward and Hescheler, Juergen (2014). ESNATS Conference - The Use of Human Embryonic Stem Cells for Novel Toxicity Testing Approaches. ATLA-Altern. Lab. Anim., 42 (2). S. 97 - 114. LONDON: SAGE PUBLICATIONS LTD. ISSN 2632-3559

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Abstract

The main achievements and results of the ESNATS project (Embryonic Stem Cell-based Novel Alternative Testing Strategies) were presented at the final project conference that was held on 15 September 2013, the day before the traditional EUSAAT (European Society for Alternatives to Animal Testing) Congress in Linz, Austria. The ESNATS project was an FP7 European Integrated Project, running from 2008 to 2013, the aim of which was to develop a novel toxicity testing platform based on embryonic stem cells (ESCs), and in particular, human ESC (hESCs), to accelerate drug development, reduce related R&D costs, and propose a powerful alternative to animal tests in the spirit of the Three Rs principles. Altogether, ESNATS offered the first proof of concept that hESCs can be used to create robust, reproducible and ready-to use test assays for predicting human toxicity. In the end, essentially five test systems were developed to an adequate level for entering possible pre-validation procedures. These methods are based on hESCs, and can be combined to study the possible effects, on the human embryo, of exposure to a chemical during the early stages of development. In addition to the presentations by the main project partners, external speakers were invited to give lectures on relevant topics, both in the field of neurotoxicity and, more generally, on the applicability of hESCs in the development of advanced in vitro tests.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Rovida, CostanzaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Vivier, ManonUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Garthoff, BernwardUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hescheler, JuergenUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-440916
DOI: 10.1177/026119291404200203
Journal or Publication Title: ATLA-Altern. Lab. Anim.
Volume: 42
Number: 2
Page Range: S. 97 - 114
Date: 2014
Publisher: SAGE PUBLICATIONS LTD
Place of Publication: LONDON
ISSN: 2632-3559
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
IN-VITRO; DEVELOPMENTAL NEUROTOXICITY; GENE-EXPRESSION; TEST SYSTEMS; VALIDATION; DIFFERENTIATION; HEPATOCYTESMultiple languages
Medicine, Research & ExperimentalMultiple languages
URI: http://kups.ub.uni-koeln.de/id/eprint/44091

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