Universität zu Köln

Lehmann, Clara ORCID: 0000-0002-7042-1578, Jung, Norma, Foerster, Katja, Koch, Nora, Leifeld, Ludger, Fischer, Julia, Mauss, Stefan, Drebber, Uta, Steffen, Hans Michael, Romerio, Fabio, Faetkenheuer, Gerd and Hartmann, Pia (2014). Longitudinal Analysis of Distribution and Function of Plasmacytoid Dendritic Cells in Peripheral Blood and Gut Mucosa of HIV Infected Patients. J. Infect. Dis., 209 (6). S. 940 - 950. CARY: OXFORD UNIV PRESS INC. ISSN 1537-6613

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Abstract

Aberrant activation of plasmacytoid dendritic cells (pDCs) with excessive production of interferon alpha (IFN alpha) represents one of the hallmarks of immune activation during chronic phase of human immunodeficiency virus (HIV) infection. A number of studies have shown that disruption of mucosal integrity in the gut is a cause of persistent immune activation. However, little is known about the role that pDCs play in this process, and our current understanding comes from the simian immunodeficiency virus macaque model. Thus, in the present study we sought to investigate the frequency and function of pDCs in peripheral blood and gut samples from HIV-infected individuals before and 6 months after initiation of antiretroviral therapy (ART). We show that circulating pDCs were depleted in ART-naive HIV+ patients, and upregulated the gut-homing receptor CD103 compared with uninfected controls. By converse, pDCs accumulated in the terminal ileum of ART-naive HIV individuals compared with controls. Baseline levels of IFNa production and markers of immune activation in gut samples of ART-naive HIV subjects were elevated. All these parameters declined after 6 months of ART. Our results suggest that in chronic HIV infection, pDCs migrate from peripheral blood to the gut-associated lymphatic tissue, where they may contribute to immune activation.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Lehmann, Clara UNSPECIFIED orcid.org/0000-0002-7042-1578 UNSPECIFIED Jung, Norma UNSPECIFIED UNSPECIFIED UNSPECIFIED Foerster, Katja UNSPECIFIED UNSPECIFIED UNSPECIFIED Koch, Nora UNSPECIFIED UNSPECIFIED UNSPECIFIED Leifeld, Ludger UNSPECIFIED UNSPECIFIED UNSPECIFIED Fischer, Julia UNSPECIFIED UNSPECIFIED UNSPECIFIED Mauss, Stefan UNSPECIFIED UNSPECIFIED UNSPECIFIED Drebber, Uta UNSPECIFIED UNSPECIFIED UNSPECIFIED Steffen, Hans Michael UNSPECIFIED UNSPECIFIED UNSPECIFIED Romerio, Fabio UNSPECIFIED UNSPECIFIED UNSPECIFIED Faetkenheuer, Gerd UNSPECIFIED UNSPECIFIED UNSPECIFIED Hartmann, Pia UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-443341
DOI:	10.1093/infdis/jit612
Journal or Publication Title:	J. Infect. Dis.
Volume:	209
Number:	6
Page Range:	S. 940 - 950
Date:	2014
Publisher:	OXFORD UNIV PRESS INC
Place of Publication:	CARY
ISSN:	1537-6613
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language IMMUNODEFICIENCY-VIRUS-INFECTION; INFLAMMATORY-BOWEL-DISEASE; CD8(+) T-CELLS; INTERFERON-ALPHA; ANTIRETROVIRAL THERAPY; LYMPHOID-TISSUE; SIV INFECTION; I INTERFERON; MICROBIAL TRANSLOCATION; GASTROINTESTINAL-TRACT Multiple languages Immunology; Infectious Diseases; Microbiology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/44334