Universität zu Köln

Johannis, Wibke, Renno, Joerg H., Klatt, Andreas R. and Wielckens, Klaus (2014). Anti-glycolipid antibodies in patients with neuropathy: A diagnostic assessment. J. Clin. Neurosci., 21 (3). S. 488 - 493. OXFORD: ELSEVIER SCI LTD. ISSN 1532-2653

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Abstract

Anti-glycolipid antibodies are associated with immune-mediated neuropathies and screening is often performed as part of the diagnostic assessment for patients presenting with peripheral neuropathy. We report our experience in testing for immunoglobulin (Ig) G and IgM anti-glycolipid (GM1, GM2, GM3, GM4, GD1a, GD1b, GD2, GD3, GT1a, GT1b, GQ1b, sulfatides) antibodies in 290 consecutive patients presenting with neuropathy. Anti-glycolipid antibodies were detected significantly more often (43%) in patients who were diagnosed with definite immune-mediated neuropathy than in patients without a final diagnosis of immune-mediated neuropathy (control group) (23%). With positive and negative predictive values of 22% and 90%, respectively, anti-glycolipid antibodies are not a very reliable diagnostic tool in early patient contact. Certain antibodies (IgM to GM2, GT1a and IgG to GM3, GD3 and GT1b) were equally or more prevalent in the control group; clinicians should be aware of this distribution when receiving positive screening results for these antibodies. Concomitant IgG and IgM reactivities were found for GM1, GM2, GD1b and sulfatides, and were detected more frequently in patients with definite immune-mediated neuropathies. (C) 2013 Elsevier Ltd. All rights reserved.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Johannis, Wibke UNSPECIFIED UNSPECIFIED UNSPECIFIED Renno, Joerg H. UNSPECIFIED UNSPECIFIED UNSPECIFIED Klatt, Andreas R. UNSPECIFIED UNSPECIFIED UNSPECIFIED Wielckens, Klaus UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-444751
DOI:	10.1016/j.jocn.2013.07.041
Journal or Publication Title:	J. Clin. Neurosci.
Volume:	21
Number:	3
Page Range:	S. 488 - 493
Date:	2014
Publisher:	ELSEVIER SCI LTD
Place of Publication:	OXFORD
ISSN:	1532-2653
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language GUILLAIN-BARRE-SYNDROME; PERIPHERAL NEUROPATHY; ANTIGANGLIOSIDE AUTOANTIBODIES; GANGLIOSIDE ANTIBODIES; MANAGEMENT Multiple languages Clinical Neurology; Neurosciences Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/44475