Zhang, Ke, Langen, Karl-Josef ORCID: 0000-0003-1101-5075, Neuner, Irene ORCID: 0000-0002-5164-8873, Stoffels, Gabriele ORCID: 0000-0001-7114-1941, Filss, Christian ORCID: 0000-0002-9927-6335, Galldiks, Norbert ORCID: 0000-0002-2485-1796, Tellmann, Lutz ORCID: 0000-0002-1154-2847, Kops, Elena Rota, Coenen, Heinz H., Herzog, Hans and Shah, Nadim J. (2014). Relationship of regional cerebral blood flow and kinetic behaviour of O-(2-F-18-fluoroethyl)-L-tyrosine uptake in cerebral gliomas. Nucl. Med. Commun., 35 (3). S. 245 - 252. PHILADELPHIA: LIPPINCOTT WILLIAMS & WILKINS. ISSN 1473-5628

Full text not available from this repository.

Abstract

ObjectivesO-(2-F-18-fluoroethyl)-l-tyrosine (F-18-FET) is an established tracer for brain tumour imaging. F-18-FET kinetics in gliomas appear to have potential for tumour grading, but the mechanisms remain unclear. The aim of this study was to explore the relationship between regional cerebral blood flow (rCBF) as measured by arterial spin labelling MRI and the kinetic behaviour of F-18-FET PET in cerebral gliomas.Materials and methodsTwenty patients with cerebral gliomas were investigated using arterial spin labelling MRI and dynamic F-18-FET PET. Time-activity curves (TACs) of F-18-FET uptake were analysed in 33 different tumour regions. The slopes of TAC during the early (0-5 min; slope(up)) and late phases of tracer uptake (17-50 min; slope(down)) were fitted using linear regression lines. In addition, TACs of each lesion were assigned to different curve patterns. Furthermore, we calculated tumour-to-brain ratios of F-18-FET uptake. The relationship between F-18-FET parameters and rCBF was determined.Results(18)F-FET uptake in the early phase (slope(up)) showed a significant correlation with rCBF (r=0.4; P=0.02). In contrast, both slope(down) and TAC patterns showed no significant correlation with rCBF. Furthermore, a significant correlation was found between rCBF and tumour-to-brain ratio (r=0.53; P=0.002).ConclusionThere is a relationship between rCBF and F-18-FET uptake in cerebral gliomas in the initial uptake phase, but the kinetic behaviour of F-18-FET uptake in the late phase is not significantly influenced by rCBF. Thus, the differential kinetic pattern of F-18-FET uptake in high-grade and low-grade gliomas appears to be determined by factors other than rCBF. (C) 2014 Wolters Kluwer Health | Lippincott Williams & Wilkins.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Zhang, KeUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Langen, Karl-JosefUNSPECIFIEDorcid.org/0000-0003-1101-5075UNSPECIFIED
Neuner, IreneUNSPECIFIEDorcid.org/0000-0002-5164-8873UNSPECIFIED
Stoffels, GabrieleUNSPECIFIEDorcid.org/0000-0001-7114-1941UNSPECIFIED
Filss, ChristianUNSPECIFIEDorcid.org/0000-0002-9927-6335UNSPECIFIED
Galldiks, NorbertUNSPECIFIEDorcid.org/0000-0002-2485-1796UNSPECIFIED
Tellmann, LutzUNSPECIFIEDorcid.org/0000-0002-1154-2847UNSPECIFIED
Kops, Elena RotaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Coenen, Heinz H.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Herzog, HansUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Shah, Nadim J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-445541
DOI: 10.1097/MNM.0000000000000036
Journal or Publication Title: Nucl. Med. Commun.
Volume: 35
Number: 3
Page Range: S. 245 - 252
Date: 2014
Publisher: LIPPINCOTT WILLIAMS & WILKINS
Place of Publication: PHILADELPHIA
ISSN: 1473-5628
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
CLINICAL-APPLICATIONS; F-18-FET PET; HUMAN BRAIN; FET PET; TRANSPORT; CONTRAST; DENSITY; MRIMultiple languages
Radiology, Nuclear Medicine & Medical ImagingMultiple languages
URI: http://kups.ub.uni-koeln.de/id/eprint/44554

Downloads

Downloads per month over past year

Altmetric

Export

Actions (login required)

View Item View Item