Grammatikos, Georgios, Lange, Christian, Susser, Simone, Schwendy, Susanne, Dikopoulos, Nektarios, Buggisch, Peter, Encke, Jens, Teuber, Gerlinde, Goeser, Tobias, Thimme, Robert, Klinker, Hartwig, Boecher, Wulf O., Schulte-Frohlinde, Ewert, Penna-Martinez, Marissa, Badenhoop, Klaus, Zeuzem, Stefan, Berg, Thomas ORCID: 0000-0003-0003-6241 and Sarrazin, Christoph (2014). Vitamin D Levels Vary during Antiviral Treatment but Are Unable to Predict Treatment Outcome in HCV Genotype 1 Infected Patients. PLoS One, 9 (2). SAN FRANCISCO: PUBLIC LIBRARY SCIENCE. ISSN 1932-6203

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Abstract

Background: Different parameters have been determined for prediction of treatment outcome in hepatitis c virus genotype 1 infected patients undergoing pegylated interferon, ribavirin combination therapy. Results on the importance of vitamin D levels are conflicting. In the present study, a comprehensive analysis of vitamin D levels before and during therapy together with single nucleotide polymorphisms involved in vitamin D metabolism in the context of other known treatment predictors has been performed. Methods: In a well characterized prospective cohort of 398 genotype 1 infected patients treated with pegylated interferon-alpha and ribavirin for 24-72 weeks (INDIV-2 study) 25-OH-vitamin D levels and different single nucleotide polymorphisms were analyzed together with known biochemical parameters for a correlation with virologic treatment outcome. Results: Fluctuations of more than 5 (10) ng/ml in 25-OH-vitamin D-levels have been observed in 66 (39) % of patients during the course of antiviral therapy and neither pretreatment nor under treatment 25-OH-vitamin D-levels were associated with treatment outcome. The DHCR7-TT-polymorphism within the 7-dehydrocholesterol-reductase showed a significant association (P = 0.031) to sustained viral response in univariate analysis. Among numerous further parameters analyzed we found that age (OR = 1.028, CI = 1.002-1.056, P = 0.035), cholesterol (OR = 0.983, CI = 0.975-0.991, P<0.001), ferritin (OR = 1.002, CI = 1.000-1.004, P = 0.033), gGT (OR = 1.467, CI = 1.073-2.006, P = 0.016) and IL28B-genotype (OR = 2.442, CI = 1.271-4.695, P = 0.007) constituted the strongest predictors of treatment response. Conclusions: While 25-OH-vitamin D-levels levels show considerable variations during the long-lasting course of antiviral therapy they do not show any significant association to treatment outcome in genotype 1 infected patients.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Grammatikos, GeorgiosUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lange, ChristianUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Susser, SimoneUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schwendy, SusanneUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Dikopoulos, NektariosUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Buggisch, PeterUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Encke, JensUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Teuber, GerlindeUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Goeser, TobiasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Thimme, RobertUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Klinker, HartwigUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Boecher, Wulf O.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schulte-Frohlinde, EwertUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Penna-Martinez, MarissaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Badenhoop, KlausUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Zeuzem, StefanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Berg, ThomasUNSPECIFIEDorcid.org/0000-0003-0003-6241UNSPECIFIED
Sarrazin, ChristophUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-445998
DOI: 10.1371/journal.pone.0087974
Journal or Publication Title: PLoS One
Volume: 9
Number: 2
Date: 2014
Publisher: PUBLIC LIBRARY SCIENCE
Place of Publication: SAN FRANCISCO
ISSN: 1932-6203
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
CHRONIC HEPATITIS-C; SUSTAINED VIROLOGICAL RESPONSE; COMMON GENETIC-DETERMINANTS; D SERUM-LEVELS; IL28B POLYMORPHISMS; INTERFERON-ALPHA; VIRAL CLEARANCE; VIRUS-INFECTION; SEVERE FIBROSIS; D INSUFFICIENCYMultiple languages
Multidisciplinary SciencesMultiple languages
URI: http://kups.ub.uni-koeln.de/id/eprint/44599

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