Universität zu Köln

Hamann, N., Zaucke, F., Heilig, J., Oberlaender, K. D., Brueggemann, G. -P. and Niehoff, A. (2014). Effect of different running modes on the morphological, biochemical, and mechanical properties of articular cartilage. Scand. J. Med. Sci. Sports, 24 (1). S. 179 - 189. HOBOKEN: WILEY-BLACKWELL. ISSN 1600-0838

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Abstract

Mechanical loading plays an important role not solely in cartilage development, but also in cartilage degeneration. Its adaptation behavior to mechanical loading has not been clearly delineated. The aim of the study was to examine the effect of different running modes (with different muscle contraction types) on morphological, biochemical, and mechanical properties of articular cartilage in the knee of growing rats. Thirty-six female Sprague-Dawley rats were randomly assigned into a nonactive age-matched control (AMC), level (LEVEL), and 20 degrees downhill (DOWN) running group (n=12 each). Running groups were trained on a treadmill for 30min/day, 5 days/week for 6 weeks. Immunohistochemical staining and analysis of expression for collagen II, collagen IX, cartilage oligomeric matrix protein (COMP), and matrilin-3, histomorphometry of femoral cartilage height and femoral COMP staining height, and indentation testing of tibial articular cartilage were performed. Rats subjected to downhill running showed a significantly (P=0.015) higher COMP staining height and a tendentially (P=0.084) higher cartilage height in the high-weight bearing area of femoral articular cartilage. Cartilage thickness, mechanical properties, and expression of cartilage network proteins in tibial cartilage remained unaffected by different running modes. Our data suggest that joint loading induced by eccentric muscle contractions during downhill running may lead to a site-specific adaptation.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Hamann, N. UNSPECIFIED UNSPECIFIED UNSPECIFIED Zaucke, F. UNSPECIFIED UNSPECIFIED UNSPECIFIED Heilig, J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Oberlaender, K. D. UNSPECIFIED UNSPECIFIED UNSPECIFIED Brueggemann, G. -P. UNSPECIFIED UNSPECIFIED UNSPECIFIED Niehoff, A. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-447409
DOI:	10.1111/j.1600-0838.2012.01513.x
Journal or Publication Title:	Scand. J. Med. Sci. Sports
Volume:	24
Number:	1
Page Range:	S. 179 - 189
Date:	2014
Publisher:	WILEY-BLACKWELL
Place of Publication:	HOBOKEN
ISSN:	1600-0838
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language OLIGOMERIC MATRIX PROTEIN; YOUNG BEAGLE DOGS; EXTRACELLULAR-MATRIX; KNEE-JOINT; INDENTATION STIFFNESS; SKELETAL DEVELOPMENT; SYNOVIAL-FLUID; COLLAGEN; OSTEOARTHRITIS; EXERCISE Multiple languages Sport Sciences Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/44740