Universität zu Köln

Richarz, R., Krapf, P., Zarrad, F., Urusova, E. A., Neumaier, B. and Zlatopolskiy, B. D. (2014). Neither azeotropic drying, nor base nor other additives: a minimalist approach to F-18-labeling. Org. Biomol. Chem., 12 (40). S. 8094 - 8100. CAMBRIDGE: ROYAL SOC CHEMISTRY. ISSN 1477-0539

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Abstract

A novel, efficient, time-saving and reliable radiolabeling procedure via nucleophilic substitution with [F-18] fluoride is described. Different radiolabeled aliphatic and aromatic compounds were prepared in high radiochemical yields simply by heating of quaternary anilinium, diaryliodonium and triarylsulfonium [F-18] fluorides in suitable solvents. The latter were obtained via direct elution of F-18(-) from an anion exchange resin with alcoholic solutions of onium precursors. Neither azeotropic evaporation of water, nor a base, nor any other additives like cryptands or crown ethers were necessary. Due to its simplicity this method should be highly suitable for automated radiosyntheses, especially in microfluidic devices.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Richarz, R. UNSPECIFIED UNSPECIFIED UNSPECIFIED Krapf, P. UNSPECIFIED UNSPECIFIED UNSPECIFIED Zarrad, F. UNSPECIFIED UNSPECIFIED UNSPECIFIED Urusova, E. A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Neumaier, B. UNSPECIFIED UNSPECIFIED UNSPECIFIED Zlatopolskiy, B. D. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-449496
DOI:	10.1039/c4ob01336k
Journal or Publication Title:	Org. Biomol. Chem.
Volume:	12
Number:	40
Page Range:	S. 8094 - 8100
Date:	2014
Publisher:	ROYAL SOC CHEMISTRY
Place of Publication:	CAMBRIDGE
ISSN:	1477-0539
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language N-SUCCINIMIDYL; F-18; PET; PEPTIDE; RADIOFLUORINATION; RADIOSYNTHESIS; PROTEINS; FLUORIDE Multiple languages Chemistry, Organic Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/44949