Universität zu Köln

Ellinger, Joerg, Bachmann, Anne, Goeke, Friederike, Behbahani, Turang E., Baumann, Claudia, Heukamp, Lukas C., Rogenhofer, Sebastian and Mueller, Stefan C. (2014). Alterations of Global Histone H3K9 and H3K27 Methylation Levels in Bladder Cancer. Urol.Int., 93 (1). S. 113 - 119. BASEL: KARGER. ISSN 1423-0399

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Abstract

Background: Epigenetic alterations, including histone modifications, play an important role during carcinogenesis. This study was designed to systematically investigate histone H3K9 and H3K27 methylation levels in bladder cancer (BCa) tissue. Methods:A tissue microarray with urothelial BCa (150 non-muscle-invasive BCa, NMIBC; 121 muscle-invasive BCa, MIBC; 31 metastatic BCa, MET) and normal urothelium (29, CTRL) specimen was used to determine the global levels of H3K9 and H3K27 mono-, di- and tri-methylation. Results: Global levels of H3K9 and H3K27 methylation were significantly higher in CTRL than in BCa, and levels in NMIBC were higher compared to MIBC. Histone nnethylation levels of MET resembled MIBC. We observed furthermore a correlation of histone nnethylation levels with pT stage (H3K9me1, H3K9me2, H3K9me3, H3K27me1, H3K27me3) and grade (H3K9nne2, H3K9me3, H3K27nne1) in NMIBC. H3K9me1, H3K9me3, H3K27me1 and H3K27me3 levels were also correlated with pT stage in MIBC. Histone modifications were not associated with recurrence-free or cancer-specific survival. Conclusions: Global histone H3K9 and H3K27 nnethylation levels are altered in BCa. (C) 2014 S. Karger AG, Basel

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Ellinger, Joerg UNSPECIFIED UNSPECIFIED UNSPECIFIED Bachmann, Anne UNSPECIFIED UNSPECIFIED UNSPECIFIED Goeke, Friederike UNSPECIFIED UNSPECIFIED UNSPECIFIED Behbahani, Turang E. UNSPECIFIED UNSPECIFIED UNSPECIFIED Baumann, Claudia UNSPECIFIED UNSPECIFIED UNSPECIFIED Heukamp, Lukas C. UNSPECIFIED UNSPECIFIED UNSPECIFIED Rogenhofer, Sebastian UNSPECIFIED UNSPECIFIED UNSPECIFIED Mueller, Stefan C. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-450088
DOI:	10.1159/000355467
Journal or Publication Title:	Urol.Int.
Volume:	93
Number:	1
Page Range:	S. 113 - 119
Date:	2014
Publisher:	KARGER
Place of Publication:	BASEL
ISSN:	1423-0399
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language RENAL-CELL CARCINOMA; PROSTATE-CANCER; DNA METHYLATION; RECURRENCE; SURVIVAL; PROGRESSION; RISK; TRIMETHYLATION; DEMETHYLASES; EXPRESSION Multiple languages Urology & Nephrology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/45008