Universität zu Köln

Morfeld, Peter, Taeger, Dirk ORCID: 0000-0002-5340-5584, Mitura, Heike, Bosch, Axel, Nordone, Adrian, Vormberg, Reinhard, McCunney, Robert and Merget, Rolf (2014). Cross-Sectional Study on Respiratory Morbidity in Workers After Exposure to Synthetic Amorphous Silica at Five German Production Plants Exposure Assessment and Exposure Estimates. J. Occup. Environ. Med., 56 (1). S. 72 - 79. PHILADELPHIA: LIPPINCOTT WILLIAMS & WILKINS. ISSN 1536-5948

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Abstract

Objectives: Synthetic amorphous silicas (SASs) are nanostructured polymorphs of silicon dioxide. We compared two different exposure assessments. Methods: This study estimated cumulative exposure to inhalable SAS dust in 484 male workers from five German SAS-producing plants. Two procedures (P1 and P2) were applied. P1 was based on an expert assessment. P2 was a multiple exposure assessment (15 scenarios) anchored by a recent measurement series (1375 personal measurements of inhalable SAS dust concentration) and used expert assessments. Results: Cumulative exposure estimates for P1 averaged 56.9 mg/m(3).yrs (range, 0.1 to 419); for a selected P2 scenario, the mean was 31.8 mg/m(3).yrs (range, 0.4 to 480), (P < 0.0001). Averages varied between the 15 P2-scenarios from 12.6 to 109.6 mg/m(3).yrs. Different time trends for SAS concentrations were observed. Conclusions: Both approaches suffer from considerable uncertainties that need to be considered in epidemiological studies.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Morfeld, Peter UNSPECIFIED UNSPECIFIED UNSPECIFIED Taeger, Dirk UNSPECIFIED orcid.org/0000-0002-5340-5584 UNSPECIFIED Mitura, Heike UNSPECIFIED UNSPECIFIED UNSPECIFIED Bosch, Axel UNSPECIFIED UNSPECIFIED UNSPECIFIED Nordone, Adrian UNSPECIFIED UNSPECIFIED UNSPECIFIED Vormberg, Reinhard UNSPECIFIED UNSPECIFIED UNSPECIFIED McCunney, Robert UNSPECIFIED UNSPECIFIED UNSPECIFIED Merget, Rolf UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-452462
DOI:	10.1097/JOM.0000000000000055
Journal or Publication Title:	J. Occup. Environ. Med.
Volume:	56
Number:	1
Page Range:	S. 72 - 79
Date:	2014
Publisher:	LIPPINCOTT WILLIAMS & WILKINS
Place of Publication:	PHILADELPHIA
ISSN:	1536-5948
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language OCCUPATIONAL EPIDEMIOLOGY; INHALATION EXPOSURE; CANCER; HEALTH; AGREEMENT; INDUSTRY Multiple languages Public, Environmental & Occupational Health Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/45246