Universität zu Köln

Amit, Moran, Yen, Tzu-Chen, Liao, Chun-Ta, Chaturvedi, Pankaj, Agarwal, Jai Prakash, Kowalski, Luiz P., Ebrahimi, Ardalan, Clark, Jonathan R., Kreppel, Matthias, Zoeller, Joachim, Fridman, Eran, Bolzoni, Villaret A., Shah, Jatin P., Binenbaum, Yoav, Patel, Snehal G. and Gil, Ziv (2013). Improvement in Survival of Patients With Oral Cavity Squamous Cell Carcinoma. Cancer, 119 (24). S. 4242 - 4249. HOBOKEN: WILEY. ISSN 1097-0142

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Abstract

BACKGROUND: An association between the survival of patients with oral cavity squamous cell carcinoma (OCSCC) and advancements in diagnosis and therapy has not been established. METHODSThis was a retrospective, longitudinal, international, population-based study of 2738 patients who underwent resection of OCSCC during 2 different decades. Characteristics of patients from 7 international cancer centers who received treatment between 1990 and 2000 (group A; n=735) were compared with patients who received treatment between 2001 and 2011 (group B; n=2003). RESULTSPatients in group B had more advanced tumors and tended to develop distant metastases more frequently than patients in group A (P=.005). More group B patients underwent selective neck dissection and received adjuvant radiotherapy (P<.001). Outcome analysis revealed a significant improvement in 5-year overall survival, from 59% for group A to 70% for group B (P<.001). There was also a significant improvement in disease-specific survival associated with operations performed before and after 2000 (from 69% to 81%, respectively; P<.001). Surgery after 2000, negative margins, adjuvant treatment, and early stage disease were independent predictors of a better outcome in multivariate analysis. The decade of treatment was an independent prognostic factor for cancer-specific mortality (hazard ratio, 0.42; 95% confidence interval, 0.3-0.6). CONCLUSIONSThe survival rate of patients with OCSCC improved significantly during the past 2 decades despite older age, more advanced disease stage, and a higher rate of distant metastases. The current results suggest that the prognosis for patients with OCSCC has improved over time, presumably because of advances in imaging and therapy. Cancer 2013;119:4242-4248. (c) 2013 American Cancer Society.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Amit, Moran UNSPECIFIED UNSPECIFIED UNSPECIFIED Yen, Tzu-Chen UNSPECIFIED UNSPECIFIED UNSPECIFIED Liao, Chun-Ta UNSPECIFIED UNSPECIFIED UNSPECIFIED Chaturvedi, Pankaj UNSPECIFIED UNSPECIFIED UNSPECIFIED Agarwal, Jai Prakash UNSPECIFIED UNSPECIFIED UNSPECIFIED Kowalski, Luiz P. UNSPECIFIED UNSPECIFIED UNSPECIFIED Ebrahimi, Ardalan UNSPECIFIED UNSPECIFIED UNSPECIFIED Clark, Jonathan R. UNSPECIFIED UNSPECIFIED UNSPECIFIED Kreppel, Matthias UNSPECIFIED UNSPECIFIED UNSPECIFIED Zoeller, Joachim UNSPECIFIED UNSPECIFIED UNSPECIFIED Fridman, Eran UNSPECIFIED UNSPECIFIED UNSPECIFIED Bolzoni, Villaret A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Shah, Jatin P. UNSPECIFIED UNSPECIFIED UNSPECIFIED Binenbaum, Yoav UNSPECIFIED UNSPECIFIED UNSPECIFIED Patel, Snehal G. UNSPECIFIED UNSPECIFIED UNSPECIFIED Gil, Ziv UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-470077
DOI:	10.1002/cncr.28357
Journal or Publication Title:	Cancer
Volume:	119
Number:	24
Page Range:	S. 4242 - 4249
Date:	2013
Publisher:	WILEY
Place of Publication:	HOBOKEN
ISSN:	1097-0142
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language INTENSITY-MODULATED RADIOTHERAPY; NECK-CANCER; ADVANCED HEAD; CHEMOTHERAPY; SURGERY; IMPACT; POPULATION; MANAGEMENT; CETUXIMAB; PATTERNS Multiple languages Oncology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/47007