Spanagel, Rainer, Durstewitz, Daniel, Hansson, Anita, Heinz, Andreas ORCID: 0000-0001-5405-9065, Kiefer, Falk, Koehr, Georg, Matthaeus, Franziska, Noethen, Markus M., Noori, Hamid R., Obermayer, Klaus, Rietschel, Marcella, Schloss, Patrick, Scholz, Henrike, Schumann, Gunter, Smolka, Michael ORCID: 0000-0001-5398-5569, Sommer, Wolfgang, Vengeliene, Valentina, Walter, Henrik ORCID: 0000-0002-9403-6121, Wurst, Wolfgang ORCID: 0000-0003-4422-7410, Zimmermann, Uli S., Smits, Yannick and Derks, Eske M. (2013). A systems medicine research approach for studying alcohol addiction. Addict. Biol., 18 (6). S. 883 - 897. HOBOKEN: WILEY. ISSN 1369-1600

Full text not available from this repository.

Abstract

According to the World Health Organization, about 2 billion people drink alcohol. Excessive alcohol consumption can result in alcohol addiction, which is one of the most prevalent neuropsychiatric diseases afflicting our society today. Prevention and intervention of alcohol binging in adolescents and treatment of alcoholism are major unmet challenges affecting our health-care system and society alike. Our newly formed German SysMedAlcoholism consortium is using a new systems medicine approach and intends (1) to define individual neurobehavioral risk profiles in adolescents that are predictive of alcohol use disorders later in life and (2) to identify new pharmacological targets and molecules for the treatment of alcoholism. To achieve these goals, we will use omics-information from epigenomics, genetics transcriptomics, neurodynamics, global neurochemical connectomes and neuroimaging (IMAGEN; Schumann etal. ) to feed mathematical prediction modules provided by two Bernstein Centers for Computational Neurosciences (Berlin and Heidelberg/Mannheim), the results of which will subsequently be functionally validated in independent clinical samples and appropriate animal models. This approach will lead to new early intervention strategies and identify innovative molecules for relapse prevention that will be tested in experimental human studies. This research program will ultimately help in consolidating addiction research clusters in Germany that can effectively conduct large clinical trials, implement early intervention strategies and impact political and healthcare decision makers.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Spanagel, RainerUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Durstewitz, DanielUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hansson, AnitaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Heinz, AndreasUNSPECIFIEDorcid.org/0000-0001-5405-9065UNSPECIFIED
Kiefer, FalkUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Koehr, GeorgUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Matthaeus, FranziskaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Noethen, Markus M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Noori, Hamid R.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Obermayer, KlausUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Rietschel, MarcellaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schloss, PatrickUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Scholz, HenrikeUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schumann, GunterUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Smolka, MichaelUNSPECIFIEDorcid.org/0000-0001-5398-5569UNSPECIFIED
Sommer, WolfgangUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Vengeliene, ValentinaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Walter, HenrikUNSPECIFIEDorcid.org/0000-0002-9403-6121UNSPECIFIED
Wurst, WolfgangUNSPECIFIEDorcid.org/0000-0003-4422-7410UNSPECIFIED
Zimmermann, Uli S.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Smits, YannickUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Derks, Eske M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-472457
DOI: 10.1111/adb.12109
Journal or Publication Title: Addict. Biol.
Volume: 18
Number: 6
Page Range: S. 883 - 897
Date: 2013
Publisher: WILEY
Place of Publication: HOBOKEN
ISSN: 1369-1600
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
GENOME-WIDE ASSOCIATION; CORTICOTROPIN-RELEASING-FACTOR; OPIOID-RECEPTOR OPRM1; NALTREXONE RESPONSE; PREFRONTAL CORTEX; SEEKING BEHAVIOR; BRAIN-FUNCTION; ETHANOL INTAKE; GENE; DEPENDENCEMultiple languages
Biochemistry & Molecular Biology; Substance AbuseMultiple languages
URI: http://kups.ub.uni-koeln.de/id/eprint/47245

Downloads

Downloads per month over past year

Altmetric

Export

Actions (login required)

View Item View Item