Universität zu Köln

Woopen, Christiane, Pauls, K. Amande M., Koy, Anne, Moro, Elena and Timmermann, Lars (2013). Early application of deep brain stimulation: Clinical and ethical aspects. Prog. Neurobiol., 110. S. 74 - 89. OXFORD: PERGAMON-ELSEVIER SCIENCE LTD. ISSN 1873-5118

Full text not available from this repository.

Abstract

Deep brain stimulation (DBS) has proven to be a successful therapeutic approach in several patients with movement disorders such as Parkinson's disease and dystonia. Hitherto its application was mainly restricted to advanced disease patients resistant to medication or with severe treatment side effects. However, there is now growing interest in earlier application of DBS, aimed at improving clinical outcomes, quality of life, and avoiding psychosocial consequences of chronic disease-related impairments. We address the clinical and ethical aspects of two early uses of DBS, (1) DBS early in the course of the disease, and (2) DBS early in life (i.e. in children). Possible benefits, risks and burdens are discussed and thoroughly considered. Further research is needed to obtain a careful balance between exposing vulnerable patients to potential severe surgical risks and excluding them from a potentially good outcome. (C) 2013 Elsevier Ltd. All rights reserved.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Woopen, Christiane UNSPECIFIED UNSPECIFIED UNSPECIFIED Pauls, K. Amande M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Koy, Anne UNSPECIFIED UNSPECIFIED UNSPECIFIED Moro, Elena UNSPECIFIED UNSPECIFIED UNSPECIFIED Timmermann, Lars UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-472613
DOI:	10.1016/j.pneurobio.2013.04.002
Journal or Publication Title:	Prog. Neurobiol.
Volume:	110
Page Range:	S. 74 - 89
Date:	2013
Publisher:	PERGAMON-ELSEVIER SCIENCE LTD
Place of Publication:	OXFORD
ISSN:	1873-5118
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language TERM-FOLLOW-UP; ADVANCED PARKINSONS-DISEASE; QUALITY-OF-LIFE; GLOBUS-PALLIDUS; DOUBLE-BLIND; SUBTHALAMIC NUCLEUS; BOTULINUM TOXIN; BILATERAL STIMULATION; SEGMENTAL DYSTONIA; MOVEMENT-DISORDERS Multiple languages Neurosciences Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/47261