Muether, Philipp S., Neuhann, Irmingard, Buhl, Christoph, Hermann, Manuel M., Kirchhof, Bernd and Fauser, Sascha (2013). INTRAOCULAR GROWTH FACTORS AND CYTOKINES IN PATIENTS WITH DRY AND NEOVASCULAR AGE-RELATED MACULAR DEGENERATION. Retin.-J. Retin. Vitr. Dis., 33 (9). S. 1809 - 1815. PHILADELPHIA: LIPPINCOTT WILLIAMS & WILKINS. ISSN 1539-2864

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Abstract

Purpose: To analyze intraocular growth factor and cytokine concentrations in eyes with different stages of age-related macular degeneration (AMD) compared with controls. Methods: The Clinical Age-Related Maculopathy Staging (CARMS) system was used for assignment of patients into the respective categories. Aqueous humor specimens were taken before cataract surgery in 21 controls (CARMS 1) and in 17 early (CARMS 2) and 16 intermediate (CARMS 3) AMD patients. In 18 neovascular (CARMS 5) AMD patients, specimens were taken immediately before anti-vascular endothelial growth factor intravitreal therapy. Luminex multiplex bead assays were conducted for endostatin, angiogenin, vascular endothelial growth factor, platelet-derived growth factor AA, placental growth factor, thrombospondin 2, and fibroblast growth factor a. Results: Vascular endothelial growth factor concentrations were elevated in CARMS 3 (P = 0.037) and tended to be elevated in CARMS 5 (P = 0.093), whereas levels in CARMS 2 (P = 0.425) were similar to CARMS 1. Platelet-derived growth factor levels were diminished in CARMS 2 (P = 0.020), with a trend to lower levels for CARMS 3 (P = 0.099) and CARMS 5 (P = 0.082) compared with CARMS 1. For CARMS 5, antiangiogenic endostatin was elevated (P < 0.002), while antiangiogenic thrombospondin 2 was reduced (P = 0.029). Conclusion: Clinical Age-Related Maculopathy Staging 3 dry AMD was associated with higher vascular endothelial growth factor levels than CARMS 5 neovascular AMD. Therefore, intraocular vascular endothelial growth factor concentrations do not seem to reflect choroidal neovascularization activity in neovascular AMD directly. Platelet-derived growth factor was decreased in most forms of AMD. The antiangiogenic endostatin was exclusively elevated in neovascular AMD, while thrombospondin 2 was reduced. Age-related macular degeneration disease seems to be associated with a generally altered cytokine system.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Muether, Philipp S.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Neuhann, IrmingardUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Buhl, ChristophUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hermann, Manuel M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kirchhof, BerndUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Fauser, SaschaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-474340
DOI: 10.1097/IAE.0b013e318285cd9e
Journal or Publication Title: Retin.-J. Retin. Vitr. Dis.
Volume: 33
Number: 9
Page Range: S. 1809 - 1815
Date: 2013
Publisher: LIPPINCOTT WILLIAMS & WILKINS
Place of Publication: PHILADELPHIA
ISSN: 1539-2864
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
AQUEOUS-HUMOR LEVELS; EPITHELIUM-DERIVED FACTOR; CHOROIDAL NEOVASCULARIZATION; MACULOPATHY; EXPRESSION; MEMBRANES; BEVACIZUMAB; PREVALENCE; ENDOSTATIN; SYSTEMMultiple languages
OphthalmologyMultiple languages
URI: http://kups.ub.uni-koeln.de/id/eprint/47434

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