Hundeshagen, G., Szameit, K., Thieme, H., Finkensieper, M., Angelov, D. N., Guntinas-Lichius, O. and Irintchev, A. (2013). DEFICIENT FUNCTIONAL RECOVERY AFTER FACIAL NERVE CRUSH IN RATS IS ASSOCIATED WITH RESTRICTED REARRANGEMENTS OF SYNAPTIC TERMINALS IN THE FACIAL NUCLEUS. Neuroscience, 248. S. 307 - 319. OXFORD: PERGAMON-ELSEVIER SCIENCE LTD. ISSN 1873-7544

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Abstract

Crush injuries of peripheral nerves typically lead to axonotmesis, axonal damage without disruption of connective tissue sheaths. Generally, human patients and experimental animals recover well after axonotmesis and the favorable outcome has been attributed to precise axonal reinnervation of the original peripheral targets. Here we assessed functionally and morphologically the long-term consequences of facial nerve axonotmesis in rats. Expectedly, we found that 5 months after crush or cryogenic nerve lesion, the numbers of motoneurons with regenerated axons and their projection pattern into the main branches of the facial nerve were similar to those in control animals suggesting precise target reinnervation. Unexpectedly, however, we found that functional recovery, estimated by vibrissal motion analysis, was incomplete at 2 months after injury and did not improve thereafter. The maximum amplitude of whisking remained substantially, by more than 30% lower than control values even 5 months after axonotmesis. Morphological analyses showed that the facial motoneurons ipsilateral to injury were innervated by lower numbers of glutamatergic terminals (-15%) and cholinergic perisomatic boutons (-26%) compared with the contralateral non-injured motoneurons. The structural deficits were correlated with functional performance of individual animals and associated with microgliosis in the facial nucleus but not with polyinnervation of muscle fibers. These results support the idea that restricted CNS plasticity and insufficient afferent inputs to motoneurons may substantially contribute to functional deficits after facial nerve injuries, possibly including pathologic conditions in humans like axonotmesis in idiopathic facial nerve (Bell's) palsy. (C) 2013 IBRO. Published by Elsevier Ltd. All rights reserved.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Hundeshagen, G.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Szameit, K.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Thieme, H.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Finkensieper, M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Angelov, D. N.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Guntinas-Lichius, O.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Irintchev, A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-475824
DOI: 10.1016/j.neuroscience.2013.06.019
Journal or Publication Title: Neuroscience
Volume: 248
Page Range: S. 307 - 319
Date: 2013
Publisher: PERGAMON-ELSEVIER SCIENCE LTD
Place of Publication: OXFORD
ISSN: 1873-7544
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
ADHESION MOLECULE L1; SPINAL-CORD-INJURY; NEURAL PLASTICITY; MOTOR NUCLEUS; CLOSE HOMOLOG; TENASCIN-C; MOTONEURONS; PROMOTES; REPAIR; REORGANIZATIONMultiple languages
NeurosciencesMultiple languages
URI: http://kups.ub.uni-koeln.de/id/eprint/47582

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