Kaehler, Christian, Isensee, Joerg ORCID: 0000-0002-3390-0051, Nonhoff, Ute, Terrey, Markus ORCID: 0000-0002-7359-4810, Hucho, Tim ORCID: 0000-0002-4147-9308, Lehrach, Hans and Krobitsch, Sylvia (2012). Ataxin-2-Like Is a Regulator of Stress Granules and Processing Bodies. PLoS One, 7 (11). SAN FRANCISCO: PUBLIC LIBRARY SCIENCE. ISSN 1932-6203
Full text not available from this repository.Abstract
Paralogs for several proteins implicated in neurodegenerative disorders have been identified and explored to further facilitate the identification of molecular mechanisms contributing to disease pathogenesis. For the disease-causing protein in spinocerebellar ataxia type 2, ataxin-2, a paralog of unknown function, termed ataxin-2-like, has been described. We discovered that ataxin-2-like associates with known interaction partners of ataxin-2, the RNA helicase DDX6 and the poly(A)-binding protein, and with ataxin-2 itself. Furthermore, we found that ataxin-2-like is a component of stress granules. Interestingly, sole ataxin-2-like overexpression led to the induction of stress granules, while a reduction of stress granules was detected in case of a low ataxin-2-like level. Finally, we observed that overexpression of ataxin-2-like as well as its reduction has an impact on the presence of microscopically visible processing bodies. Thus, our results imply a functional overlap between ataxin-2-like and ataxin-2, and further indicate a role for ataxin-2-like in the regulation of stress granules and processing bodies.
Item Type: | Journal Article | ||||||||||||||||||||||||||||||||
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URN: | urn:nbn:de:hbz:38-478382 | ||||||||||||||||||||||||||||||||
DOI: | 10.1371/journal.pone.0050134 | ||||||||||||||||||||||||||||||||
Journal or Publication Title: | PLoS One | ||||||||||||||||||||||||||||||||
Volume: | 7 | ||||||||||||||||||||||||||||||||
Number: | 11 | ||||||||||||||||||||||||||||||||
Date: | 2012 | ||||||||||||||||||||||||||||||||
Publisher: | PUBLIC LIBRARY SCIENCE | ||||||||||||||||||||||||||||||||
Place of Publication: | SAN FRANCISCO | ||||||||||||||||||||||||||||||||
ISSN: | 1932-6203 | ||||||||||||||||||||||||||||||||
Language: | English | ||||||||||||||||||||||||||||||||
Faculty: | Unspecified | ||||||||||||||||||||||||||||||||
Divisions: | Unspecified | ||||||||||||||||||||||||||||||||
Subjects: | no entry | ||||||||||||||||||||||||||||||||
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URI: | http://kups.ub.uni-koeln.de/id/eprint/47838 |
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