Kaehler, Christian, Isensee, Joerg ORCID: 0000-0002-3390-0051, Nonhoff, Ute, Terrey, Markus ORCID: 0000-0002-7359-4810, Hucho, Tim ORCID: 0000-0002-4147-9308, Lehrach, Hans and Krobitsch, Sylvia (2012). Ataxin-2-Like Is a Regulator of Stress Granules and Processing Bodies. PLoS One, 7 (11). SAN FRANCISCO: PUBLIC LIBRARY SCIENCE. ISSN 1932-6203

Full text not available from this repository.

Abstract

Paralogs for several proteins implicated in neurodegenerative disorders have been identified and explored to further facilitate the identification of molecular mechanisms contributing to disease pathogenesis. For the disease-causing protein in spinocerebellar ataxia type 2, ataxin-2, a paralog of unknown function, termed ataxin-2-like, has been described. We discovered that ataxin-2-like associates with known interaction partners of ataxin-2, the RNA helicase DDX6 and the poly(A)-binding protein, and with ataxin-2 itself. Furthermore, we found that ataxin-2-like is a component of stress granules. Interestingly, sole ataxin-2-like overexpression led to the induction of stress granules, while a reduction of stress granules was detected in case of a low ataxin-2-like level. Finally, we observed that overexpression of ataxin-2-like as well as its reduction has an impact on the presence of microscopically visible processing bodies. Thus, our results imply a functional overlap between ataxin-2-like and ataxin-2, and further indicate a role for ataxin-2-like in the regulation of stress granules and processing bodies.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Kaehler, ChristianUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Isensee, JoergUNSPECIFIEDorcid.org/0000-0002-3390-0051UNSPECIFIED
Nonhoff, UteUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Terrey, MarkusUNSPECIFIEDorcid.org/0000-0002-7359-4810UNSPECIFIED
Hucho, TimUNSPECIFIEDorcid.org/0000-0002-4147-9308UNSPECIFIED
Lehrach, HansUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Krobitsch, SylviaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-478382
DOI: 10.1371/journal.pone.0050134
Journal or Publication Title: PLoS One
Volume: 7
Number: 11
Date: 2012
Publisher: PUBLIC LIBRARY SCIENCE
Place of Publication: SAN FRANCISCO
ISSN: 1932-6203
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
SPINOCEREBELLAR ATAXIA TYPE-2; MESSENGER-RNA DECAY; ARGININE METHYLATION; TRINUCLEOTIDE REPEAT; SPLICING FACTORS; PROTEIN-PROTEIN; HUMAN PAT1B; P-BODIES; GENE; IDENTIFICATIONMultiple languages
Multidisciplinary SciencesMultiple languages
URI: http://kups.ub.uni-koeln.de/id/eprint/47838

Downloads

Downloads per month over past year

Altmetric

Export

Actions (login required)

View Item View Item