Universität zu Köln

Vallboehmer, D., Bollschweiler, E., Brabender, J., Wedemeyer, I., Grimminger, P. P., Metzger, R., Schroeder, W., Gutschow, C., Hoelscher, A. H. and Drebber, U. (2012). Evaluation of histological regression grading systems in the neoadjuvant therapy of rectal cancer. Int. J. Colorectal Dis., 27 (10). S. 1295 - 1302. NEW YORK: SPRINGER. ISSN 0179-1958

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Abstract

Neoadjuvant treatment options have been developed to improve survival of patients with locally advanced rectal cancer. As only patients with a major histopatholocial response benefit from this preoperative therapy, several tumor regression grading systems have been developed. However, currently no accepted comprehensive grading system for clinical use is available. Therefore, we studied the impact of four histological regression grading systems in the neoadjuvant therapy of rectal cancer. In this retrospective study, 85 patients with locally advanced rectal cancer were included. All patients received a neoadjuvant radiochemotherapy followed by surgical resection. The histological regression grading was evaluated using four classification systems: (1) grading system by the Japanese society of colorectal cancer, (2) grading system by Junker-Muller, (3) grading system by Dworak, (4) Cologne grading system. The four classification systems were analyzed for their prognostic impact. The following significant correlations were detected between the four classification systems and the ypTNM categories: (1) patients with a ypT3/4 category had significantly more often a worse histopathologic response in all four grading systems (p = 0.001); (2) a ypN0 category was significantly correlated with good histopathologic response only in the Cologne grading system; (3) in the Junker-Muller and Dworak grading systems, a ypM0 category was significantly correlated with a good histopathologic response (p = 0.046; p = 0.03). However, none of the used classification systems had a prognostic impact on survival. Currently, none of the analyzed histological regression grading systems is effective for clinical use.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Vallboehmer, D. UNSPECIFIED UNSPECIFIED UNSPECIFIED Bollschweiler, E. UNSPECIFIED UNSPECIFIED UNSPECIFIED Brabender, J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Wedemeyer, I. UNSPECIFIED UNSPECIFIED UNSPECIFIED Grimminger, P. P. UNSPECIFIED UNSPECIFIED UNSPECIFIED Metzger, R. UNSPECIFIED UNSPECIFIED UNSPECIFIED Schroeder, W. UNSPECIFIED UNSPECIFIED UNSPECIFIED Gutschow, C. UNSPECIFIED UNSPECIFIED UNSPECIFIED Hoelscher, A. H. UNSPECIFIED UNSPECIFIED UNSPECIFIED Drebber, U. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-481927
DOI:	10.1007/s00384-012-1487-6
Journal or Publication Title:	Int. J. Colorectal Dis.
Volume:	27
Number:	10
Page Range:	S. 1295 - 1302
Date:	2012
Publisher:	SPRINGER
Place of Publication:	NEW YORK
ISSN:	0179-1958
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language TUMOR-REGRESSION; PREOPERATIVE RADIOTHERAPY; PROGNOSTIC-SIGNIFICANCE; CHEMORADIOTHERAPY; RADIOCHEMOTHERAPY; CHEMORADIATION; SURVIVAL; OUTCOMES Multiple languages Gastroenterology & Hepatology; Surgery Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/48192