Daniels, Christine, Krack, Paul ORCID: 0000-0002-3508-7295, Volkmann, Jens ORCID: 0000-0002-9570-593X, Raethjen, Jan, Pinsker, Markus O., Kloss, Manja, Tronnier, Volker, Schnitzler, Alfons ORCID: 0000-0002-6414-7939, Wojtecki, Lars, Boetzel, Kai, Danek, Adrian ORCID: 0000-0001-8857-5383, Hilker, Ruediger, Sturm, Volker, Kupsch, Andreas, Karner, Elfriede, Deuschl, Guenther ORCID: 0000-0002-4176-9196 and Witt, Karsten (2011). Is improvement in the quality of life after subthalamic nucleus stimulation in Parkinson's disease predictable? Mov. Disord., 26 (14). S. 2516 - 2522. MALDEN: WILEY-BLACKWELL. ISSN 0885-3185

Full text not available from this repository.

Abstract

Deep brain stimulation (DBS) of the subthalamic nucleus (STN) significantly improves quality of life (QoL) in PD. However, QoL fails to improve in a relevant proportion of patients. We studied clinical baseline and progression parameters associated with improvement in QoL after DBS. Data from a German randomized, controlled study comparing DBS (60 patients) with best medical treatment (59 patients) were analyzed. Changes in patients' QoL were assessed using the Parkinson's Disease Questionnaire (PDQ-39) at baseline and at the 6-month follow-up. For the STN-DBS patients, the changes in PDQ-39 were correlated with predefined clinical preoperative and progression parameters. Scores for QoL improved after STN-DBS for 57% of the patients, and for 43% patients, they did not improve. Patients with improvement in QoL showed significantly higher cumulative daily off time. Changes in the PDQ-39 showed a significant positive correlation with the cumulative daily off time at baseline. Logistic regression analysis revealed that 1 additional hour off time at baseline increases the odds for improvement on PDQ-39 by a factor of 1.33 (odds ratio). In the postoperative course, changes in the PDQ-39 significantly correlated with the reduction of cumulative daily off time, an improvement on the UPDRS (UPDRS III off), and positive mood changes. Among the baseline parameters, the cumulative daily off time is the strongest predictor for improvement in disease-related QoL after DBS. Improvement in QoL after STN-DBS is also correlated with changes in motor functions and changes in depression and anxiety. (c) 2011 Movement Disorder Society

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Daniels, ChristineUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Krack, PaulUNSPECIFIEDorcid.org/0000-0002-3508-7295UNSPECIFIED
Volkmann, JensUNSPECIFIEDorcid.org/0000-0002-9570-593XUNSPECIFIED
Raethjen, JanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Pinsker, Markus O.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kloss, ManjaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Tronnier, VolkerUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schnitzler, AlfonsUNSPECIFIEDorcid.org/0000-0002-6414-7939UNSPECIFIED
Wojtecki, LarsUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Boetzel, KaiUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Danek, AdrianUNSPECIFIEDorcid.org/0000-0001-8857-5383UNSPECIFIED
Hilker, RuedigerUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Sturm, VolkerUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kupsch, AndreasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Karner, ElfriedeUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Deuschl, GuentherUNSPECIFIEDorcid.org/0000-0002-4176-9196UNSPECIFIED
Witt, KarstenUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-484142
DOI: 10.1002/mds.23907
Journal or Publication Title: Mov. Disord.
Volume: 26
Number: 14
Page Range: S. 2516 - 2522
Date: 2011
Publisher: WILEY-BLACKWELL
Place of Publication: MALDEN
ISSN: 0885-3185
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
DEEP-BRAIN-STIMULATION; TRIALMultiple languages
Clinical NeurologyMultiple languages
URI: http://kups.ub.uni-koeln.de/id/eprint/48414

Downloads

Downloads per month over past year

Altmetric

Export

Actions (login required)

View Item View Item