Universität zu Köln

Rizzo, Manfredi, Macario, Alberto J. L., de Macario, Everly Conway, Gouni-Berthold, Ioanna, Berthold, Heiner K., Rini, Giovam Battista, Zummo, Giovanni and Cappello, Francesco ORCID: 0000-0001-9288-1148 (2011). Heat Shock Protein-60 and Risk for Cardiovascular Disease. Curr. Pharm. Design, 17 (33). S. 3662 - 3669. SHARJAH: BENTHAM SCIENCE PUBL LTD. ISSN 1873-4286

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Abstract

Cardiovascular disease (CVD) is a leading cause of morbidity and mortality worldwide. There is growing evidence that molecular chaperones, many of which are heat shock proteins HSPs, are involved in CVD pathogenesis. In this review we focus on HSP60, the human mitochondrial chaperone that also displays extramitochondrial and extracellular functions. HSP60 is typically cytoprotective but a number of stress conditions determine its conversion to a potentially toxic molecule for cells and tissues. We present illustrative examples of specific subtypes of CVD where HSP60 is implicated in the initiation and/or progression of disease. The data not only indicate a pathogenic role for HSP60 but also its potential as a biomarker with applications for diagnosis, assessing prognosis and response to treatment, as well as for preventing and treating CVD.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Rizzo, Manfredi UNSPECIFIED UNSPECIFIED UNSPECIFIED Macario, Alberto J. L. UNSPECIFIED UNSPECIFIED UNSPECIFIED de Macario, Everly Conway UNSPECIFIED UNSPECIFIED UNSPECIFIED Gouni-Berthold, Ioanna UNSPECIFIED UNSPECIFIED UNSPECIFIED Berthold, Heiner K. UNSPECIFIED UNSPECIFIED UNSPECIFIED Rini, Giovam Battista UNSPECIFIED UNSPECIFIED UNSPECIFIED Zummo, Giovanni UNSPECIFIED UNSPECIFIED UNSPECIFIED Cappello, Francesco UNSPECIFIED orcid.org/0000-0001-9288-1148 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-485664
DOI:	10.2174/138161211798220981
Journal or Publication Title:	Curr. Pharm. Design
Volume:	17
Number:	33
Page Range:	S. 3662 - 3669
Date:	2011
Publisher:	BENTHAM SCIENCE PUBL LTD
Place of Publication:	SHARJAH
ISSN:	1873-4286
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language HEAT-SHOCK-PROTEIN; LOW-DENSITY-LIPOPROTEIN; SERUM-SOLUBLE HEAT-SHOCK-PROTEIN-60; REGULATORY T-CELLS; CHLAMYDIA-PNEUMONIAE; CLINICAL-SIGNIFICANCE; ANTIBODY-LEVELS; CYTOSOLIC HEAT-SHOCK-PROTEIN-60; MYOCARDIAL-INFARCTION; HELICOBACTER-PYLORI Multiple languages Pharmacology & Pharmacy Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/48566