Universität zu Köln

Debrah, Alexander Yaw, Batsa, Linda, Albers, Anna, Mand, Sabine, Toliat, Mohammad Reza, Nuernberg, Peter, Adjei, Ohene, Hoerauf, Achim and Pfarr, Kenneth ORCID: 0000-0003-3096-2465 (2011). Transforming growth factor-beta 1 variant Leu10Pro is associated with both lack of microfilariae and differential microfilarial loads in the blood of persons infected with lymphatic filariasis. Hum. Immunol., 72 (11). S. 1143 - 1149. NEW YORK: ELSEVIER SCIENCE INC. ISSN 1879-1166

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Abstract

Antigen testing and ultrasound detection have shown that many persons are infected with Wuchereria bancrofti even though they do not have microfilariae (Mf) in the blood. To ascertain the role of human host immunogenetics on the lack of circulating Mf in the blood, 152 lymphatic filariasis (LF)-infected patients comprising 118 patients with microfilaremic (Mf+, patent) infection and 34 patients with latent (Mf-, antigen-positive) infection were recruited and genotyped for association of single nucleotide polymorphisms of TGF-beta 1 and differential Mf load and/or lack of Mf in the blood from infected persons in Ghana. An association was found between the TGF-beta 1 Leu10Pro variant and lack of Mf in the blood. Patients with latent infection had a higher frequency of the Leu/Leu genotype than patients with patent infection (p = 0.03). Secondary analysis revealed an association among the three possible Leu10Pro genotypes and different Mf loads in the blood. In conclusion, the differential Mf loads and the lack of Mf in the blood of patients is likely to have a genetic basis. Because the adult worms are responsible for pathology, these results underscore the need for a review of using only Mf detection in blood smears for diagnosis of LF infection in endemic areas. This information is also important for the mapping and surveillance activities of national and global programs for elimination of LF. (C) 2011 American Society for Histocompatibility and Immunogenetics. Published by Elsevier Inc. All rights reserved.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Debrah, Alexander Yaw UNSPECIFIED UNSPECIFIED UNSPECIFIED Batsa, Linda UNSPECIFIED UNSPECIFIED UNSPECIFIED Albers, Anna UNSPECIFIED UNSPECIFIED UNSPECIFIED Mand, Sabine UNSPECIFIED UNSPECIFIED UNSPECIFIED Toliat, Mohammad Reza UNSPECIFIED UNSPECIFIED UNSPECIFIED Nuernberg, Peter UNSPECIFIED UNSPECIFIED UNSPECIFIED Adjei, Ohene UNSPECIFIED UNSPECIFIED UNSPECIFIED Hoerauf, Achim UNSPECIFIED UNSPECIFIED UNSPECIFIED Pfarr, Kenneth UNSPECIFIED orcid.org/0000-0003-3096-2465 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-486318
DOI:	10.1016/j.humimm.2011.07.305
Journal or Publication Title:	Hum. Immunol.
Volume:	72
Number:	11
Page Range:	S. 1143 - 1149
Date:	2011
Publisher:	ELSEVIER SCIENCE INC
Place of Publication:	NEW YORK
ISSN:	1879-1166
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language GROWTH-FACTOR-BETA; CELL SUPPRESSOR FACTOR; ONCHOCERCA-VOLVULUS; HELMINTH INFECTION; ANTIGEN; GENE; SUSCEPTIBILITY; INTERLEUKIN-5; POLYMORPHISM; LYMPHEDEMA Multiple languages Immunology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/48631