Universität zu Köln

Basak, Grzegorz W., Mikala, Gabor, Koristek, Zdenek ORCID: 0000-0002-0478-854X, Jaksic, Ozren, Basic-Kinda, Sandra, Cegledi, Andrea, Reti, Marienn, Masszi, Tamas ORCID: 0000-0003-2322-9863, Mayer, Jiri, Giebel, Sebastian ORCID: 0000-0002-4827-4401, Huebel, Kai, Labar, Boris and Wiktor-Jedrzejczak, Wieslaw (2011). Plerixafor to rescue failing chemotherapy-based stem cell mobilization: it's not too late. Leuk. Lymphoma, 52 (9). S. 1711 - 1720. LONDON: INFORMA HEALTHCARE. ISSN 1042-8194

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Abstract

Plerixafor can rescue the outcome of failing chemotherapy-based stem cell mobilization. However, the optimal time for plerixafor injection in this setting has not been determined. This was investigated by retrospective analysis of data from 48 mobilizations with plerixafor, chemotherapy, and granulocyte-colony stimulating factor (G-CSF). The required yield of 2.0 x 10(6) CD34+ cells/kg was collected from 71% of patients; the median total yield was 4.1 x 10(6) CD34+ cells/kg. Patients to whom plerixafor was administered late (>= 15 days) after chemotherapy, after a long duration (>= 13 days) of treatment with G-CSF, or when the white blood cell count was high (>= 20 x 10(9)/L) were mobilized as efficiently as other patients. Plerixafor was shown to rescue mobilizations at a comparable rate in patients with critically low levels of peripheral blood CD34+ cells (53/mL) and those with higher concentrations. These data suggest that late administration of plerixafor in the course of chemotherapy-based mobilization does not contribute to the failure of this strategy.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Basak, Grzegorz W. UNSPECIFIED UNSPECIFIED UNSPECIFIED Mikala, Gabor UNSPECIFIED UNSPECIFIED UNSPECIFIED Koristek, Zdenek UNSPECIFIED orcid.org/0000-0002-0478-854X UNSPECIFIED Jaksic, Ozren UNSPECIFIED UNSPECIFIED UNSPECIFIED Basic-Kinda, Sandra UNSPECIFIED UNSPECIFIED UNSPECIFIED Cegledi, Andrea UNSPECIFIED UNSPECIFIED UNSPECIFIED Reti, Marienn UNSPECIFIED UNSPECIFIED UNSPECIFIED Masszi, Tamas UNSPECIFIED orcid.org/0000-0003-2322-9863 UNSPECIFIED Mayer, Jiri UNSPECIFIED UNSPECIFIED UNSPECIFIED Giebel, Sebastian UNSPECIFIED orcid.org/0000-0002-4827-4401 UNSPECIFIED Huebel, Kai UNSPECIFIED UNSPECIFIED UNSPECIFIED Labar, Boris UNSPECIFIED UNSPECIFIED UNSPECIFIED Wiktor-Jedrzejczak, Wieslaw UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-490085
DOI:	10.3109/10428194.2011.578312
Journal or Publication Title:	Leuk. Lymphoma
Volume:	52
Number:	9
Page Range:	S. 1711 - 1720
Date:	2011
Publisher:	INFORMA HEALTHCARE
Place of Publication:	LONDON
ISSN:	1042-8194
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language COLONY-STIMULATING FACTOR; MULTIPLE-MYELOMA; CXCR4 ANTAGONIST; COLLECTION; AMD3100; TRANSPLANTATION; STRATEGIES; VOLUNTEERS Multiple languages Oncology; Hematology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/49008