Universität zu Köln

Church, Chris, Moir, Lee ORCID: 0000-0003-4829-3597, McMurray, Fiona ORCID: 0000-0003-4147-5064, Girard, Christophe, Banks, Gareth T., Teboul, Lydia ORCID: 0000-0002-2789-8637, Wells, Sara, Bruening, Jens C., Nolan, Patrick M., Ashcroft, Frances M. and Cox, Roger D. (2010). Overexpression of Fto leads to increased food intake and results in obesity. Nature Genet., 42 (12). S. 1086 - 1094. NEW YORK: NATURE PUBLISHING GROUP. ISSN 1061-4036

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Abstract

Genome-wide association studies have identified SNPs within FTO, the human fat mass and obesity-associated gene, that are strongly associated with obesity. Individuals homozygous for the at-risk rs9939609 A allele weigh, on average, similar to 3 kg more than individuals with the low-risk T allele. Mice that lack FTO function and/or Fto expression display increased energy expenditure and a lean phenotype. We show here that ubiquitous overexpression of Fto leads to a dose-dependent increase in body and fat mass, irrespective of whether mice are fed a standard or a high-fat diet. Our results suggest that increased body mass results primarily from increased food intake. Mice with increased Fto expression on a high-fat diet develop glucose intolerance. This study provides the first direct evidence that increased Fto expression causes obesity in mice.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Church, Chris UNSPECIFIED UNSPECIFIED UNSPECIFIED Moir, Lee UNSPECIFIED orcid.org/0000-0003-4829-3597 UNSPECIFIED McMurray, Fiona UNSPECIFIED orcid.org/0000-0003-4147-5064 UNSPECIFIED Girard, Christophe UNSPECIFIED UNSPECIFIED UNSPECIFIED Banks, Gareth T. UNSPECIFIED UNSPECIFIED UNSPECIFIED Teboul, Lydia UNSPECIFIED orcid.org/0000-0002-2789-8637 UNSPECIFIED Wells, Sara UNSPECIFIED UNSPECIFIED UNSPECIFIED Bruening, Jens C. UNSPECIFIED UNSPECIFIED UNSPECIFIED Nolan, Patrick M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Ashcroft, Frances M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Cox, Roger D. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-491930
DOI:	10.1038/ng.713
Journal or Publication Title:	Nature Genet.
Volume:	42
Number:	12
Page Range:	S. 1086 - 1094
Date:	2010
Publisher:	NATURE PUBLISHING GROUP
Place of Publication:	NEW YORK
ISSN:	1061-4036
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language BODY-MASS INDEX; ENERGY-EXPENDITURE; PHYSICAL-ACTIVITY; GENE-EXPRESSION; ADULT OBESITY; FAT; VARIANTS; CHILDREN; MOUSE; POLYMORPHISMS Multiple languages Genetics & Heredity Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/49193