Universität zu Köln

Bauer, Marcus, Moebus, Susanne, Moehlenkamp, Stefan, Dragano, Nico, Nonnemacher, Michael, Fuchsluger, Miriam, Kessler, Christoph, Jakobs, Hermann, Memmesheimer, Michael, Erbel, Raimund, Joeckel, Karl-Heinz and Hoffmann, Barbara (2010). Urban Particulate Matter Air Pollution Is Associated With Subclinical Atherosclerosis Results From the HNR (Heinz Nixdorf Recall) Study. J. Am. Coll. Cardiol., 56 (22). S. 1803 - 1809. NEW YORK: ELSEVIER SCIENCE INC. ISSN 0735-1097

Full text not available from this repository.

Abstract

Objectives The aim of this study was to investigate the association of long-term residential exposure to fine particles with carotid intima-media thickness (CIMT). Background Experimental and epidemiological evidence suggest that long-term exposure to air pollution might have a causal role in atherogenesis, but epidemiological findings are still inconsistent. We investigate whether urban particulate matter (PM) air pollution is associated with CIMT, a marker of subclinical atherosclerosis. Methods We used baseline data (2000 to 2003) from the HNR (Heinz Nixdorf Recall) study, a population-based cohort of 4,814 participants, 45 to 75 years of age. We assessed residential long-term exposure to PM with a chemistry transport model and measured distance to high traffic. Multiple linear regression was used to estimate associations of air pollutants and traffic with CIMT, adjusting for each other, city of residence, age, sex, diabetes, and lifestyle variables. Results Median CIMT of the 3,380 analyzed participants was 0.66 mm (interquartile range 0.16 mm). An interdecile range increase in PM2.5 (4.2 mu g/m(3)), PM10 (6.7 mu g/m(3)), and distance to high traffic (1,939 m) was associated with a 4.3% (95% confidence interval [CI]: 1.9% to 6.7%), 1.7% (95% CI: -0.7% to 4.1%), and 1.2% (95% CI: -0.2% to 2.6%) increase in CIMT, respectively. Conclusions Our study shows a clear association of long-term exposure to PM2.5 with atherosclerosis. This finding strengthens the hypothesized role of PM2.5 as a risk factor for atherogenesis. (J Am Coll Cardiol 2010;56:1803-8) (C) 2010 by the American College of Cardiology Foundation

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Bauer, Marcus UNSPECIFIED UNSPECIFIED UNSPECIFIED Moebus, Susanne UNSPECIFIED UNSPECIFIED UNSPECIFIED Moehlenkamp, Stefan UNSPECIFIED UNSPECIFIED UNSPECIFIED Dragano, Nico UNSPECIFIED UNSPECIFIED UNSPECIFIED Nonnemacher, Michael UNSPECIFIED UNSPECIFIED UNSPECIFIED Fuchsluger, Miriam UNSPECIFIED UNSPECIFIED UNSPECIFIED Kessler, Christoph UNSPECIFIED UNSPECIFIED UNSPECIFIED Jakobs, Hermann UNSPECIFIED UNSPECIFIED UNSPECIFIED Memmesheimer, Michael UNSPECIFIED UNSPECIFIED UNSPECIFIED Erbel, Raimund UNSPECIFIED UNSPECIFIED UNSPECIFIED Joeckel, Karl-Heinz UNSPECIFIED UNSPECIFIED UNSPECIFIED Hoffmann, Barbara UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-492239
DOI:	10.1016/j.jacc.2010.04.065
Journal or Publication Title:	J. Am. Coll. Cardiol.
Volume:	56
Number:	22
Page Range:	S. 1803 - 1809
Date:	2010
Publisher:	ELSEVIER SCIENCE INC
Place of Publication:	NEW YORK
ISSN:	0735-1097
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language LONG-TERM EXPOSURE; CORONARY ATHEROSCLEROSIS; RESIDENTIAL EXPOSURE; DISEASE; HUMANS; RISK Multiple languages Cardiac & Cardiovascular Systems Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/49223