Universität zu Köln

Levin, Y., Wang, L., Schwarz, E., Koethe, D., Leweke, F. M. and Bahn, S. (2010). Global proteomic profiling reveals altered proteomic signature in schizophrenia serum. Mol. Psychiatr., 15 (11). S. 1088 - 1101. LONDON: NATURE PUBLISHING GROUP. ISSN 1476-5578

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Abstract

Schizophrenia is one of the most severe psychiatric disorders affecting 1% of the world population. There is yet no empirical method to validate the diagnosis of the disease. The identification of an underlying molecular alteration could lead to an improved disease understanding and may yield an objective panel of biomarkers to aid in the diagnosis of this devastating disease. Presented is the largest reported liquid chromatography-mass spectrometry-based proteomic profiling study investigating serum samples taken from first-onset drug-naive patients compared with samples collected from healthy volunteers. The results of this large-scale study are presented along with enzyme-linked immunosorbent assay-based validation data. Molecular Psychiatry (2010) 15, 1088-1100; doi:10.1038/mp.2009.54; published online 23 June 2009

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Levin, Y. UNSPECIFIED UNSPECIFIED UNSPECIFIED Wang, L. UNSPECIFIED UNSPECIFIED UNSPECIFIED Schwarz, E. UNSPECIFIED UNSPECIFIED UNSPECIFIED Koethe, D. UNSPECIFIED UNSPECIFIED UNSPECIFIED Leweke, F. M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Bahn, S. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-493761
DOI:	10.1038/mp.2009.54
Journal or Publication Title:	Mol. Psychiatr.
Volume:	15
Number:	11
Page Range:	S. 1088 - 1101
Date:	2010
Publisher:	NATURE PUBLISHING GROUP
Place of Publication:	LONDON
ISSN:	1476-5578
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language APOLIPOPROTEIN-A-I; HIGH-DENSITY-LIPOPROTEIN; ESTER TRANSFER PROTEIN; LECITHIN-CHOLESTEROL ACYLTRANSFERASE; PHOSPHOLIPID TRANSFER PROTEIN; SITE-DIRECTED MUTAGENESIS; CASSETTE TRANSPORTER A1; LIPID TRANSFER PROTEINS; E-DEFICIENT MICE; HUMAN APOA-II Multiple languages Biochemistry & Molecular Biology; Neurosciences; Psychiatry Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/49376