Velthorst, Eva ORCID: 0000-0002-9240-2909, Nieman, Darien H., Linszen, Don, Becker, Hiske, de Haan, Lieuwe, Dingemans, Peter M., Birchwood, Max ORCID: 0000-0002-7476-0171, Patterson, Paul ORCID: 0000-0003-3310-8635, Salokangas, Raimo K. R., Heinimaa, Markus, Heinz, Andreas ORCID: 0000-0001-5405-9065, Juckel, Georg, von Reventlow, Heinrich Graf, French, Paul, Stevens, Helen, Schultze-Lutter, Frauke, Klosterkoetter, Joachim and Ruhrmann, Stephan ORCID: 0000-0002-6022-2364 (2010). Disability in people clinically at high risk of psychosis. Br. J. Psychiatry, 197 (4). S. 278 - 285. CAMBRIDGE: CAMBRIDGE UNIV PRESS. ISSN 1472-1465

Full text not available from this repository.

Abstract

Background Decline in social functioning occurs in individuals who later develop psychosis. Aims To investigate whether baseline differences in disability are present in those who do and those who do not make a transition to psychosis in a group clinically at high risk and whether disability is a risk factor for transition. Method Prospective multicentre, naturalistic field study with an 18-month follow-up period on 245 help-seeking individuals clinically at high risk. Disability was assessed with the Disability Assessment Schedule of the World Health Organization (WHODAS-II). Results At baseline, the transition group displayed significantly greater difficulties in making new friends (z = -3.40, P=0.001), maintaining a friendship (z = -3.00, P = 0.003), dealing with people they do not know (z = -2.28, P = 0.023) and joining community activities (z = -2.0, P = 0.05) compared with the non-transition group. In Cox regression, difficulties in getting along with people significantly contributed to the prediction of transition to psychosis in our sample (beta=0.569, s.e. = 0.184, Wald = 9.548, P = 0.002, hazard ratio (HR) = 1.767, 95% CI 1.238-2.550). Conclusions Certain domains of social disability might contribute to the prediction of psychosis in a sample clinically at high risk.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Velthorst, EvaUNSPECIFIEDorcid.org/0000-0002-9240-2909UNSPECIFIED
Nieman, Darien H.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Linszen, DonUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Becker, HiskeUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
de Haan, LieuweUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Dingemans, Peter M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Birchwood, MaxUNSPECIFIEDorcid.org/0000-0002-7476-0171UNSPECIFIED
Patterson, PaulUNSPECIFIEDorcid.org/0000-0003-3310-8635UNSPECIFIED
Salokangas, Raimo K. R.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Heinimaa, MarkusUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Heinz, AndreasUNSPECIFIEDorcid.org/0000-0001-5405-9065UNSPECIFIED
Juckel, GeorgUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
von Reventlow, Heinrich GrafUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
French, PaulUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Stevens, HelenUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schultze-Lutter, FraukeUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Klosterkoetter, JoachimUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ruhrmann, StephanUNSPECIFIEDorcid.org/0000-0002-6022-2364UNSPECIFIED
URN: urn:nbn:de:hbz:38-495173
DOI: 10.1192/bjp.bp.109.075036
Journal or Publication Title: Br. J. Psychiatry
Volume: 197
Number: 4
Page Range: S. 278 - 285
Date: 2010
Publisher: CAMBRIDGE UNIV PRESS
Place of Publication: CAMBRIDGE
ISSN: 1472-1465
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
ULTRA-HIGH-RISK; ASSESSMENT-SCHEDULE-II; SCHIZOPHRENIA; DISORDERS; PREDICTION; INDIVIDUALS; VALIDATION; TRANSITION; DEPRESSION; PRODROMEMultiple languages
PsychiatryMultiple languages
URI: http://kups.ub.uni-koeln.de/id/eprint/49517

Downloads

Downloads per month over past year

Altmetric

Export

Actions (login required)

View Item View Item