Universität zu Köln

Meemboor, Sonja, Mertens, Janina, Flenner, Eva, Groneck, Laura, Zingarelli, Alessandra, Gamstaetter, Thomas, Bessler, Martina, Seeger, Jens M., Kashkar, Hamid, Odenthal, Margarete and Kalka-Moll, Wiltrud Maria (2010). Interleukin-6 is essential for zwitterionic polysaccharide-mediated abscess formation. Innate Immun., 16 (5). S. 310 - 322. LONDON: SAGE PUBLICATIONS LTD. ISSN 1753-4267

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Abstract

Abscess formation associated with secondary peritonitis causes severe morbidity and can be fatal. Formation of abscesses requires the presence of CD4(+) T-cells. Zwitterionic polysaccharides (ZPSs) represent a novel class of immunomodulatory bacterial antigens that stimulate CD4(+) T-cells in a major histocompatibility complex (MHC) class II-dependent manner. The capsular polysaccharide Sp1 of Streptococcus pneumoniae serotype 1 possesses a zwitterionic charge with free amino groups and promotes T-cell-dependent abscess formation in an experimental mouse model. So far, nothing is known about the function of Interleukin (IL)-6 in intraperitoneal abscess formation. Here, we demonstrate that macrophages and dendritic cells (DCs), the most prevalent professional antigen-presenting cells involved in the formation of abscesses, secrete Interleukin (IL)-6 and are incorporated in the abscess capsule. Sp1 inhibits apoptosis of CD4(+) T-cells and causes IL-17 expression by CD4(+) T-cells in an IL-6-dependent manner. Abrogation of the Sp1-induced pleiotropic effects of IL-6 in IL-6-deficient mice and mice treated with an IL-6- specific neutralizing antibody results in significant inhibition of abscess formation. The data delineate the essential role of IL-6 in the linkage of innate and adaptive immunity in polysaccharide-mediated abscess formation.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Meemboor, Sonja UNSPECIFIED UNSPECIFIED UNSPECIFIED Mertens, Janina UNSPECIFIED UNSPECIFIED UNSPECIFIED Flenner, Eva UNSPECIFIED UNSPECIFIED UNSPECIFIED Groneck, Laura UNSPECIFIED UNSPECIFIED UNSPECIFIED Zingarelli, Alessandra UNSPECIFIED UNSPECIFIED UNSPECIFIED Gamstaetter, Thomas UNSPECIFIED UNSPECIFIED UNSPECIFIED Bessler, Martina UNSPECIFIED UNSPECIFIED UNSPECIFIED Seeger, Jens M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Kashkar, Hamid UNSPECIFIED UNSPECIFIED UNSPECIFIED Odenthal, Margarete UNSPECIFIED UNSPECIFIED UNSPECIFIED Kalka-Moll, Wiltrud Maria UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-495654
DOI:	10.1177/1753425909346974
Journal or Publication Title:	Innate Immun.
Volume:	16
Number:	5
Page Range:	S. 310 - 322
Date:	2010
Publisher:	SAGE PUBLICATIONS LTD
Place of Publication:	LONDON
ISSN:	1753-4267
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language TUMOR-NECROSIS-FACTOR; INFLAMMATORY-BOWEL-DISEASE; T-CELLS; BACTEROIDES-FRAGILIS; CAPSULAR POLYSACCHARIDES; INTRAABDOMINAL INFECTIONS; ANTIGEN PRESENTATION; DENDRITIC CELLS; KNOCKOUT MICE; FACTOR-ALPHA Multiple languages Biochemistry & Molecular Biology; Immunology; Medicine, Research & Experimental; Microbiology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/49565