Universität zu Köln

Vasyutina, Elena ORCID: 0000-0001-9722-3419 and Treier, Mathias (2010). Molecular mechanisms in renal degenerative disease. Semin. Cell Dev. Biol., 21 (8). S. 831 - 838. LONDON: ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD. ISSN 1084-9521

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Abstract

Chronic kidney disease (CKD) has become a major public health problem worldwide. Therefore, a considerable effort is currently directed to understand the molecular mechanisms of renal degenerative processes. Regardless of their initiating cause, all chronic kidney diseases (CKD) develop at some level organ fibrosis that interferes with kidney function. This is also true for the two most common inherited CKD syndromes, nephronophthitis and polycystic kidney disease, whose primary defects reside within the cilium of kidney epithelial cells. A cohort of elegant recent studies has elicited the role of the primary cilium as a versatile mechanosensory organelle that also might coordinate cross-talk between multiple signaling pathways. In addition, epigenetic mechanisms are now realized to be essential in the maintenance of adult renal architecture. In this review, we will discuss recent advances in our understanding of the signaling systems implicated in kidney homeostasis and repair. (C) 2010 Elsevier Ltd. All rights reserved.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Vasyutina, Elena UNSPECIFIED orcid.org/0000-0001-9722-3419 UNSPECIFIED Treier, Mathias UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-496254
DOI:	10.1016/j.semcdb.2010.08.010
Journal or Publication Title:	Semin. Cell Dev. Biol.
Volume:	21
Number:	8
Page Range:	S. 831 - 838
Date:	2010
Publisher:	ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
Place of Publication:	LONDON
ISSN:	1084-9521
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language UNILATERAL URETERAL OBSTRUCTION; UBIQUITIN-DEPENDENT DEGRADATION; PLANAR CELL POLARITY; FINGER PROTEIN GLIS2; GROWTH-FACTOR-BETA; MESENCHYMAL TRANSITION; SONIC HEDGEHOG; PRIMARY CILIUM; KIDNEY DEVELOPMENT; FIBROSIS Multiple languages Cell Biology; Developmental Biology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/49625