Yildiz, Ipek, Mantz, Melissa ORCID: 0000-0001-7254-5331, Hartmann, Michael ORCID: 0000-0003-4828-958X, Zeier, Tatyana, Kessel, Jana, Thurow, Corinna, Gatz, Christiane, Petzsch, Patrick, Kohrer, Karl and Zeier, Juergen (2021). The mobile SAR signal N-hydroxypipecolic acid induces NPR1-dependent transcriptional reprogramming and immune priming. Plant Physiol., 186 (3). S. 1679 - 1706. CARY: OXFORD UNIV PRESS INC. ISSN 1532-2548

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Abstract

N-hydroxypipecolic acid (NHP) accumulates in the plant foliage in response to a localized microbial attack and induces systemic acquired resistance (SAR) in distant leaf tissue. Previous studies indicated that pathogen inoculation of Arabidopsis (Arabidopsis thaliana) systemically activates SAR-related transcriptional reprogramming and a primed immune status in strict dependence of FLAVIN-DEPENDENT MONOOXYGENASE 1 (FMO1), which mediates the endogenous biosynthesis of NHP. Here, we show that elevations of NHP by exogenous treatment are sufficient to induce a SAR-reminiscent transcriptional response that mobilizes key components of immune surveillance and signal transduction. Exogenous NHP primes Arabidopsis wild-type and NHP-deficient fmo1 plants for a boosted induction of pathogen-triggered defenses, such as the biosynthesis of the stress hormone salicylic acid (SA), accumulation of the phytoalexin camalexin and branched-chain amino acids, as well as expression of defense-related genes. NHP also sensitizes the foliage systemically for enhanced SA-inducible gene expression. NHP-triggered SAR, transcriptional reprogramming, and defense priming are fortified by SA accumulation, and require the function of the transcriptional coregulator NON-EXPRESSOR OF PR GENES1 (NPR1). Our results suggest that NPR1 transduces NHP-activated immune signaling modes with predominantly SA-dependent and minor SA-independent features. They further support the notion that NHP functions as a mobile immune regulator capable of moving independently of active SA signaling between leaves to systemically activate immune responses.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Yildiz, IpekUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Mantz, MelissaUNSPECIFIEDorcid.org/0000-0001-7254-5331UNSPECIFIED
Hartmann, MichaelUNSPECIFIEDorcid.org/0000-0003-4828-958XUNSPECIFIED
Zeier, TatyanaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kessel, JanaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Thurow, CorinnaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Gatz, ChristianeUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Petzsch, PatrickUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kohrer, KarlUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Zeier, JuergenUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-578373
DOI: 10.1093/plphys/kiab166
Journal or Publication Title: Plant Physiol.
Volume: 186
Number: 3
Page Range: S. 1679 - 1706
Date: 2021
Publisher: OXFORD UNIV PRESS INC
Place of Publication: CARY
ISSN: 1532-2548
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
SYSTEMIC ACQUIRED-RESISTANCE; HYDROXY-PIPECOLIC ACID; PROGRAMMED CELL-DEATH; RECEPTOR-LIKE KINASE; SALICYLIC-ACID; DISEASE RESISTANCE; BIOSYNTHESIS; DEFENSE; PROTEIN; NPR1Multiple languages
Plant SciencesMultiple languages
URI: http://kups.ub.uni-koeln.de/id/eprint/57837

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