Universität zu Köln

Deenen, Daniel A., Maljaars, Bert, Sebeke, Lukas C., de Jager, Bram, Heijman, Edwin, Grull, Holger and Heemels, W. P. Maurice H. (2021). Offset-Free Model Predictive Temperature Control for Ultrasound-Based Hyperthermia Cancer Treatments. IEEE Trans. Control Syst. Technol., 29 (6). S. 2351 - 2366. PISCATAWAY: IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC. ISSN 1558-0865

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Abstract

Heating cancer cells over an extended period of time, referred to as hyperthermia, has been proven to enhance the effects of chemotherapy and radiotherapy without inducing additional toxicity or undesirable side effects, and is therefore considered a highly valuable adjuvant therapy in cancer treatment. In this work, a model predictive control (MPC) setup is developed for improving performance and robustness in regulating the temperature for magnetic-resonance-guided high-intensity focused ultrasound (MR-HIFU) hyperthermia treatments. The proposed control design incorporates a disturbance estimator as encountered in offset-free MPC that is able to remove the steady-state temperature error caused by plant-model mismatch. For the considered healthcare application, such modeling errors are inevitable in practice due to the high variability of tissue properties in patients, some of which even exhibit time- and temperature-dependent behavior due to the body's thermoregulatory response, combined with the fact that extensive model identification is undesirable in the clinic. The controller's performance is demonstrated by means of in vivo experiments on a porcine thigh muscle using a clinical MR-HIFU treatment setup.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Deenen, Daniel A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Maljaars, Bert UNSPECIFIED UNSPECIFIED UNSPECIFIED Sebeke, Lukas C. UNSPECIFIED UNSPECIFIED UNSPECIFIED de Jager, Bram UNSPECIFIED UNSPECIFIED UNSPECIFIED Heijman, Edwin UNSPECIFIED UNSPECIFIED UNSPECIFIED Grull, Holger UNSPECIFIED UNSPECIFIED UNSPECIFIED Heemels, W. P. Maurice H. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-582275
DOI:	10.1109/TCST.2020.3036169
Journal or Publication Title:	IEEE Trans. Control Syst. Technol.
Volume:	29
Number:	6
Page Range:	S. 2351 - 2366
Date:	2021
Publisher:	IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC
Place of Publication:	PISCATAWAY
ISSN:	1558-0865
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language INTENSITY FOCUSED ULTRASOUND; BLOOD-FLOW; LOCAL HYPERTHERMIA Multiple languages Automation & Control Systems; Engineering, Electrical & Electronic Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/58227