Universität zu Köln

Doppler, Christopher E. J. ORCID: 0000-0002-1341-0389, Smit, Julia A. M., Hommelsen, Maximilian ORCID: 0000-0003-1972-0465, Seger, Aline, Horsager, Jacob ORCID: 0000-0001-6098-0045, Kinnerup, Martin B., Hansen, Allan K., Fedorova, Tatyana D., Knudsen, Karoline, Otto, Marit, Nahimi, Adjmal, Borghammer, Per ORCID: 0000-0001-6391-8052 and Sommerauer, Michael (2021). Microsleep disturbances are associated with noradrenergic dysfunction in Parkinson's disease. Sleep, 44 (8). CARY: OXFORD UNIV PRESS INC. ISSN 1550-9109

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Abstract

Study Objectives: Parkinson's disease (PD) commonly involves degeneration of sleep-wake regulating brainstem nuclei; likewise, sleep-wake disturbances are highly prevalent in PD patients. As polysomnography macroparameters typically show only minor changes in PD, we investigated sleep microstructure, particularly cyclic alternating pattern (CAP), and its relation to alterations of the noradrenergic system in these patients. Methods: We analyzed 27 PD patients and 13 healthy control (HC) subjects who underwent overnight polysomnography and C-11-MeNER positron emission tomography for evaluation of noradrenaline transporter density. Sleep macroparameters, as well as CAP metrics, were evaluated according to the consensus statement from 2001. Statistical analysis comprised group comparisons and correlation analysis of CAP metrics with clinical characteristics of PD patients as well as noradrenaline transporter density. Results: PD patients and HC subjects were comparable in demographic characteristics (age, sex, body mass index) and polysomnography macroparameters. CAP rate as well as A index differed significantly between groups, with PD patients having a lower CAP rate (46.7 6.6% versus 38.0 +/- 11.6%, p = 0.015) and lower A index (49.0 +/- 8.7/hour versus 40.1 +/- 15.4/hour, p = 0.042). In PD patients, both CAP metrics correlated significantly with diminished noradrenaline transporter density in arousal prompting brainstem nuclei (locus coeruleus, raphe nuclei) as well as arousal propagating brain structures like thalamus and bitemporal cortex. Conclusions: Sleep microstructure is more severely altered than sleep macrostructure in PD patients and is associated with widespread dysfunction of the noradrenergic arousal system.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Doppler, Christopher E. J. UNSPECIFIED orcid.org/0000-0002-1341-0389 UNSPECIFIED Smit, Julia A. M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Hommelsen, Maximilian UNSPECIFIED orcid.org/0000-0003-1972-0465 UNSPECIFIED Seger, Aline UNSPECIFIED UNSPECIFIED UNSPECIFIED Horsager, Jacob UNSPECIFIED orcid.org/0000-0001-6098-0045 UNSPECIFIED Kinnerup, Martin B. UNSPECIFIED UNSPECIFIED UNSPECIFIED Hansen, Allan K. UNSPECIFIED UNSPECIFIED UNSPECIFIED Fedorova, Tatyana D. UNSPECIFIED UNSPECIFIED UNSPECIFIED Knudsen, Karoline UNSPECIFIED UNSPECIFIED UNSPECIFIED Otto, Marit UNSPECIFIED UNSPECIFIED UNSPECIFIED Nahimi, Adjmal UNSPECIFIED UNSPECIFIED UNSPECIFIED Borghammer, Per UNSPECIFIED orcid.org/0000-0001-6391-8052 UNSPECIFIED Sommerauer, Michael UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-582385
DOI:	10.1093/sleep/zsab040
Journal or Publication Title:	Sleep
Volume:	44
Number:	8
Date:	2021
Publisher:	OXFORD UNIV PRESS INC
Place of Publication:	CARY
ISSN:	1550-9109
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language ALTERNATING PATTERN CAP; SLEEP BEHAVIOR DISORDER; BRAIN; SYSTEM; PARAMETERS; RAPHE; PET Multiple languages Clinical Neurology; Neurosciences Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/58238