Universität zu Köln

Mooney, Brian C. ORCID: 0000-0002-4546-017X, Mantz, Melissa ORCID: 0000-0001-7254-5331, Graciet, Emmanuelle ORCID: 0000-0003-3548-8213 and Huesgen, Pitter F. (2021). Cutting the line: manipulation of plant immunity by bacteria type III effector proteases. J. Exp. Bot., 72 (9). S. 3395 - 3410. OXFORD: OXFORD UNIV PRESS. ISSN 1460-2431

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Abstract

Pathogens and their hosts are engaged in an evolutionary arms race. Pathogen-derived effectors promote virulence by targeting components of a host's innate immune system, while hosts have evolved proteins that sense effectors and trigger a pathogen-specific immune response. Many bacterial effectors are translocated into host cells using type III secretion systems. Type III effector proteases irreversibly modify host proteins by cleavage of peptide bonds and are prevalent among both plant and animal bacterial pathogens. In plants, the study of model effector proteases has yielded important insights into the virulence mechanisms employed by pathogens to overcome their host's immune response, as well as into the mechanisms deployed by their hosts to detect these effector proteases and counteract their effects. In recent years, the study of a larger number of effector proteases, across a wider range of pathogens, has yielded novel insights into their functions and recognition. One key limitation that remains is the lack of methods to detect protease cleavage at the proteome-wide level. We review known substrates and mechanisms of plant pathogen type III effector proteases and compare their functions with those of known type III effector proteases of mammalian pathogens. Finally, we discuss approaches to uncover their function on a system-wide level.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Mooney, Brian C. UNSPECIFIED orcid.org/0000-0002-4546-017X UNSPECIFIED Mantz, Melissa UNSPECIFIED orcid.org/0000-0001-7254-5331 UNSPECIFIED Graciet, Emmanuelle UNSPECIFIED orcid.org/0000-0003-3548-8213 UNSPECIFIED Huesgen, Pitter F. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-584309
DOI:	10.1093/jxb/erab095
Journal or Publication Title:	J. Exp. Bot.
Volume:	72
Number:	9
Page Range:	S. 3395 - 3410
Date:	2021
Publisher:	OXFORD UNIV PRESS
Place of Publication:	OXFORD
ISSN:	1460-2431
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language NUCLEOTIDE-BINDING SITE; DISEASE RESISTANCE GENE; PROGRAMMED CELL-DEATH; PV. TOMATO DC3000; NF-KAPPA-B; PSEUDOMONAS-SYRINGAE; TRIGGERED IMMUNITY; AVIRULENCE PROTEIN; ERWINIA-AMYLOVORA; INFLAMMATORY CASPASES Multiple languages Plant Sciences Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/58430