Heusser, Karsten ORCID: 0000-0002-2571-5585, Heusser, Ramona, Jordan, Jens, Urechie, Vasile, Diedrich, Andre and Tank, Jens (2021). Baroreflex Curve Fitting Using a WYSIWYG Boltzmann Sigmoidal Equation. Front. Neurosci., 15. LAUSANNE: FRONTIERS MEDIA SA. ISSN 1662-453X

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Abstract

Arterial baroreflex assessment using vasoactive substances enables investigators to collect data pairs over a wide range of blood pressures and reflex reactions. These data pairs relate intervals between heartbeats or sympathetic neural activity to blood pressure values. In an X-Y plot the data points scatter around a sigmoidal curve. After fitting the parameters of a sigmoidal function to the data, the graph's characteristics represent a rather comprehensive quantitative reflex description. Variants of the 4-parameter Boltzmann sigmoidal equation are widely used for curve fitting. Unfortunately, their 'slope parameters' do not correspond to the graph's actual slope which complicates the analysis and bears the risk of misreporting. We propose a modified Boltzmann sigmoidal function with preserved goodness of fit whose parameters are one-to-one equivalent to the sigmoidal curve's characteristics.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Heusser, KarstenUNSPECIFIEDorcid.org/0000-0002-2571-5585UNSPECIFIED
Heusser, RamonaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Jordan, JensUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Urechie, VasileUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Diedrich, AndreUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Tank, JensUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-584814
DOI: 10.3389/fnins.2021.697582
Journal or Publication Title: Front. Neurosci.
Volume: 15
Date: 2021
Publisher: FRONTIERS MEDIA SA
Place of Publication: LAUSANNE
ISSN: 1662-453X
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
SYMPATHETIC-NERVE ACTIVITY; HEART-RATE; BARORECEPTOR REFLEX; PERIAQUEDUCTAL GRAY; ACUTE SHIFTS; SENSITIVITY; RESPONSES; ARTERIAL; LESIONS; RABBITMultiple languages
NeurosciencesMultiple languages
URI: http://kups.ub.uni-koeln.de/id/eprint/58481

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