Universität zu Köln

Gerlach, Darius A., Manuel, Jorge ORCID: 0000-0003-1983-1448, Hoff, Alex, Kronsbein, Hendrik, Hoffmann, Fabian ORCID: 0000-0002-3199-9924, Heusser, Karsten ORCID: 0000-0002-2571-5585, Ehmke, Heimo ORCID: 0000-0003-3465-7185, Jordan, Jens ORCID: 0000-0003-4518-0706, Tank, Jens ORCID: 0000-0002-5672-1187 and Beissner, Florian ORCID: 0000-0003-0513-7551 (2021). Medullary and Hypothalamic Functional Magnetic Imaging During Acute Hypoxia in Tracing Human Peripheral Chemoreflex Responses. Hypertension, 77 (4). S. 1372 - 1383. PHILADELPHIA: LIPPINCOTT WILLIAMS & WILKINS. ISSN 1524-4563

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Abstract

Hypoxia-sensitive peripheral carotid chemoreceptors, which regulate sympathetic outflow from the brain stem, are promising antihypertensive treatment targets. However, the central nervous pathways integrating human peripheral chemoreflexes are poorly understood. We combined high-resolution functional magnetic resonance imaging with physiological profiling to elucidate hypothalamic and medullary responses to acute hypoxia. We exposed 12 healthy men (29.7 +/- 6.6 years) to 5 hypoxic episodes each by breathing 10% oxygen for 180 seconds followed by 90 seconds of normoxia during high-resolution subcortical functional magnetic resonance imaging. We recorded beat-by-beat finger blood pressure, ECG, and peripheral oxygen saturation (Spo(2)). We analyzed functional magnetic resonance imaging data through independent component analysis, correlation with systolic blood pressure and Spo(2), and functional connectivity analysis by dual regression. On average Spo(2) decreased by 12 +/- 3% (P<0.01) during hypoxia while heart rate increased by 3 +/- 7 bpm (P<0.01). Systolic blood pressure was unchanged. Brain stem-centered analyses revealed 5 distinct hypoxia-responsive regions around the nucleus of the solitary tract, nucleus ambiguus/intermediate reticular nucleus, dorsal motor nucleus of the vagal nerve, spinal trigeminal nucleus, and inferior olivary nucleus. Hypothalamus-centered analysis revealed 3 such regions around the arcuate nucleus, anterior hypothalamic area/lateral hypothalamic area, and paraventricular nucleus. During hypoxia, these regions showed altered functional connectivity with various medullary and hypothalamic areas. We conclude that high-resolution functional magnetic resonance imaging reveals subcortical systems engaged by acute hypoxia, which likely correspond to the peripheral chemoreceptor pathway. Our methodology may have utility in studying peripheral chemoreflex contributions to cardiovascular disease and responses to peripheral chemoreceptor modulation. Registration: URL: . Unique identifier: DRKS00013101.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Gerlach, Darius A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Manuel, Jorge UNSPECIFIED orcid.org/0000-0003-1983-1448 UNSPECIFIED Hoff, Alex UNSPECIFIED UNSPECIFIED UNSPECIFIED Kronsbein, Hendrik UNSPECIFIED UNSPECIFIED UNSPECIFIED Hoffmann, Fabian UNSPECIFIED orcid.org/0000-0002-3199-9924 UNSPECIFIED Heusser, Karsten UNSPECIFIED orcid.org/0000-0002-2571-5585 UNSPECIFIED Ehmke, Heimo UNSPECIFIED orcid.org/0000-0003-3465-7185 UNSPECIFIED Jordan, Jens UNSPECIFIED orcid.org/0000-0003-4518-0706 UNSPECIFIED Tank, Jens UNSPECIFIED orcid.org/0000-0002-5672-1187 UNSPECIFIED Beissner, Florian UNSPECIFIED orcid.org/0000-0003-0513-7551 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-590045
DOI:	10.1161/HYPERTENSIONAHA.120.16385
Journal or Publication Title:	Hypertension
Volume:	77
Number:	4
Page Range:	S. 1372 - 1383
Date:	2021
Publisher:	LIPPINCOTT WILLIAMS & WILKINS
Place of Publication:	PHILADELPHIA
ISSN:	1524-4563
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language Peripheral Vascular Disease Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/59004