Orlovskaya, Viktoriya V., Craig, Austin S., Fedorova, Olga S., Kuznetsova, Olga F., Neumaier, Bernd ORCID: 0000-0001-5425-3116, Krasikova, Raisa N. and Zlatopolskiy, Boris D. (2021). Production of 6-l-[F-18]Fluoro-m-tyrosine in an Automated Synthesis Module for C-11-Labeling. Molecules, 26 (18). BASEL: MDPI. ISSN 1420-3049

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Abstract

6-l-[F-18]Fluoro-m-tyrosine (6-l-[F-18]FMT) represents a valuable alternative to 6-l-[F-18]FDOPA which is conventionally used for the diagnosis and staging of Parkinson's disease. However, clinical applications of 6-l-[F-18]FMT have been limited by the paucity of practical production methods for its automated production. Herein we describe the practical preparation of 6-l-[F-18]FMT using alcohol-enhanced Cu-mediated radiofluorination of Bpin-substituted chiral Ni(II) complex in the presence of non-basic Bu4ONTf using a volatile iPrOH/MeCN mixture as reaction solvent. A simple and fast radiolabeling procedure afforded the tracer in 20.0 +/- 3.0% activity yield within 70 min. The developed method was directly implemented onto a modified TracerLab FX C Pro platform originally designed for C-11-labeling. This method enables an uncomplicated switch between C-11- and F-18-labeling. The simplicity of the developed procedure enables its easy adaptation to other commercially available remote-controlled synthesis units and paves the way for a widespread application of 6-l-[F-18]FMT in the clinic.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Orlovskaya, Viktoriya V.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Craig, Austin S.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Fedorova, Olga S.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kuznetsova, Olga F.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Neumaier, BerndUNSPECIFIEDorcid.org/0000-0001-5425-3116UNSPECIFIED
Krasikova, Raisa N.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Zlatopolskiy, Boris D.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-591138
DOI: 10.3390/molecules26185550
Journal or Publication Title: Molecules
Volume: 26
Number: 18
Date: 2021
Publisher: MDPI
Place of Publication: BASEL
ISSN: 1420-3049
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
PARKINSONS-DISEASE; AMINO-ACIDS; CURIE LEVEL; M-TYROSINE; L-DOPA; RADIOFLUORINATION; F-18-FLUORINATION; TRACERS; ANALOGS; ESTERSMultiple languages
Biochemistry & Molecular Biology; Chemistry, MultidisciplinaryMultiple languages
URI: http://kups.ub.uni-koeln.de/id/eprint/59113

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