Hammes, Jochen, Bischof, Gerard N., Bohn, Karl P., Onur, Oezguer, Schneider, Anja ORCID: 0000-0001-9540-8700, Fliessbach, Klaus, Hoenig, Merle C., Jessen, Frank, Neumaier, Bernd ORCID: 0000-0001-5425-3116, Drzezga, Alexander ORCID: 0000-0001-6018-716X and van Eimeren, Thilo ORCID: 0000-0002-6951-2325 (2021). One-Stop Shop: F-18-Flortaucipir PET Differentiates Amyloid-Positive and -Negative Forms of Neurodegenerative Diseases. J. Nucl. Med., 62 (2). S. 240 - 247. RESTON: SOC NUCLEAR MEDICINE INC. ISSN 1535-5667

Full text not available from this repository.

Abstract

Tau protein aggregations are a hallmark of amyloid-associated Alzheimer disease and some forms of non-amyloid-associated frontotemporal lobar degeneration. In recent years, several tracers for in vivo tau imaging have been under evaluation. This study investigated the ability of F-18-flortaucipir PET not only to assess tau positivity but also to differentiate between amyloid-positive and-negative forms of neurodegeneration on the basis of different F-18-flortaucipir PET signatures. Methods: The F-18-flortaucipir PET data of 35 patients with amyloid-positive neurodegeneration, 19 patients with amyloidnegative neurodegeneration, and 17 healthy controls were included in a data-driven scaled subprofile model (SSM)/principal-component analysis (PCA) identifying spatial covariance patterns. SSM/PCA pattern expression strengths were tested for their ability to predict amyloid status in a receiver-operating-characteristic analysis and validated with a leave-one-out approach. Results: Pattern expression strengths predicted amyloid status with a sensitivity of 0.94 and a specificity of 0.83. A support vector machine classification based on pattern expression strengths in 2 different SSM/PCA components yielded a prediction accuracy of 98%. Anatomically, prediction performance was driven by parietooccipital gray matter in amyloid-positive patients versus predominant white matter binding in amyloid-negative patients. Conclusion: SSM/PCA-derived binding patterns of F-18-flortaucipir differentiate between amyloid-positive and-negative neurodegenerative diseases with high accuracy. F-18-flortaucipir PET alone may convey additional information equivalent to that from amyloid PET. Together with a perfusion-weighted early-phase acquisition (F-18-FDG PET-equivalent), a single scan potentially contains comprehensive information on amyloid (A), tau (T), and neurodegeneration (N) status as required by recent biomarker classification algorithms (A/T/N).

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Hammes, JochenUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bischof, Gerard N.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bohn, Karl P.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Onur, OezguerUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schneider, AnjaUNSPECIFIEDorcid.org/0000-0001-9540-8700UNSPECIFIED
Fliessbach, KlausUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hoenig, Merle C.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Jessen, FrankUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Neumaier, BerndUNSPECIFIEDorcid.org/0000-0001-5425-3116UNSPECIFIED
Drzezga, AlexanderUNSPECIFIEDorcid.org/0000-0001-6018-716XUNSPECIFIED
van Eimeren, ThiloUNSPECIFIEDorcid.org/0000-0002-6951-2325UNSPECIFIED
URN: urn:nbn:de:hbz:38-596681
DOI: 10.2967/jnumed.120.244061
Journal or Publication Title: J. Nucl. Med.
Volume: 62
Number: 2
Page Range: S. 240 - 247
Date: 2021
Publisher: SOC NUCLEAR MEDICINE INC
Place of Publication: RESTON
ISSN: 1535-5667
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
TAU; NEUROPATHOLOGY; NETWORKS; BRAINMultiple languages
Radiology, Nuclear Medicine & Medical ImagingMultiple languages
URI: http://kups.ub.uni-koeln.de/id/eprint/59668

Downloads

Downloads per month over past year

Altmetric

Export

Actions (login required)

View Item View Item