Chellappa, Sarah L., Qian, Jingyi, Vujovic, Nina, Morris, Christopher J., Nedeltcheva, Arlet, Nguyen, Hoa, Rahman, Nishath, Heng, Su Wei, Kelly, Lauren, Kerlin-Monteiro, Kayla, Srivastav, Suhina, Wang, Wei, Aeschbach, Daniel, Czeisler, Charles A., Shea, Steven A., Adler, Gail K., Garaulet, Marta ORCID: 0000-0002-4066-3509 and Scheer, Frank A. J. L. (2021). Daytime eating prevents internal circadian misalignment and glucose intolerance in night work. Sci. Adv., 7 (49). WASHINGTON: AMER ASSOC ADVANCEMENT SCIENCE. ISSN 2375-2548

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Abstract

Night work increases diabetes risk. Misalignment between the central circadian clock and daily behaviors, typical in night workers, impairs glucose tolerance, likely due to internal misalignment between central and peripheral circadian rhythms. Whether appropriate circadian alignment of eating can prevent internal circadian misalignment and glucose intolerance is unknown. In a 14-day circadian paradigm, we assessed glycemic control during simulated night work with either nighttime or daytime eating. Assessment of central (body temperature) and peripheral (glucose and insulin) endogenous circadian rhythms happened during constant routine protocols before and after simulated night work. Nighttime eating led to misalignment between central and peripheral (glucose) endogenous circadian rhythms and impaired glucose tolerance, whereas restricting meals to daytime prevented it. These findings offer a behavioral approach to preventing glucose intolerance in shift workers.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Chellappa, Sarah L.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Qian, JingyiUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Vujovic, NinaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Morris, Christopher J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Nedeltcheva, ArletUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Nguyen, HoaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Rahman, NishathUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Heng, Su WeiUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kelly, LaurenUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kerlin-Monteiro, KaylaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Srivastav, SuhinaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Wang, WeiUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Aeschbach, DanielUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Czeisler, Charles A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Shea, Steven A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Adler, Gail K.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Garaulet, MartaUNSPECIFIEDorcid.org/0000-0002-4066-3509UNSPECIFIED
Scheer, Frank A. J. L.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-598172
DOI: 10.1126/sciadv.abg9910
Journal or Publication Title: Sci. Adv.
Volume: 7
Number: 49
Date: 2021
Publisher: AMER ASSOC ADVANCEMENT SCIENCE
Place of Publication: WASHINGTON
ISSN: 2375-2548
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
FOOD-INTAKE; SHIFT WORK; INSULIN-RESISTANCE; RISK; SLEEP; TIME; METABOLISM; TOLERANCE; OSCILLATORS; DESYNCHRONYMultiple languages
Multidisciplinary SciencesMultiple languages
URI: http://kups.ub.uni-koeln.de/id/eprint/59817

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