Universität zu Köln

Jost, Stefanie T., Visser-Vandewalle, Veerle, Rizos, Alexandra, Loehrer, Philipp A., Silverdale, Monty, Evans, Julian, Samuel, Michael, Petry-Schmelzer, Jan Niklas, Sauerbier, Anna ORCID: 0000-0003-0966-5933, Gronostay, Alexandra, Barbe, Michael T. ORCID: 0000-0003-1149-8054, Fink, Gereon R. ORCID: 0000-0002-8230-1856, Ashkan, Keyoumars, Antonini, Angelo ORCID: 0000-0003-1040-2807, Martinez-Martin, Pablo, Chaudhuri, K. Ray, Timmermann, Lars and Dafsari, Haidar S. (2021). Non-motor predictors of 36-month quality of life after subthalamic stimulation in Parkinson disease. npj Parkinsons Dis., 7 (1). BERLIN: NATURE RESEARCH. ISSN 2373-8057

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Abstract

To identify predictors of 36-month follow-up quality of life (QoL) outcome after bilateral subthalamic nucleus deep brain stimulation (STN-DBS) in Parkinson's disease (PD). In this ongoing, prospective, multicenter international study (Cologne, Manchester, London) including 73 patients undergoing STN-DBS, we assessed the following scales preoperatively and at 6-month and 36-month follow-up: PD Questionnaire-8 (PDQ-8), NMSScale (NMSS), Scales for Outcomes in PD (SCOPA)-motor examination, -activities of daily living, and -complications, and levodopa equivalent daily dose (LEDD). We analyzed factors associated with QoL improvement at 36-month follow-up based on (1) correlations between baseline test scores and QoL improvement, (2) step-wise linear regressions with baseline test scores as independent and QoL improvement as dependent variables, (3) logistic regressions and receiver operating characteristic curves using a dichotomized variable QoL responders/non-responders. At both follow-ups, NMSS total score, SCOPA-motor examination, and -complications improved and LEDD was reduced significantly. PDQ-8 improved at 6-month follow-up with subsequent decrements in gains at 36-month follow-up when 61.6% of patients were categorized as QoL non-responders. Correlations, linear, and logistic regression analyses found greater PDQ-8 improvements in patients with younger age, worse PDQ-8, and worse specific NMS at baseline, such as 'difficulties experiencing pleasure' and 'problems sustaining concentration'. Baseline SCOPA scores were not associated with PDQ-8 changes. Our results provide evidence that 36-month QoL changes depend on baseline neuropsychological and neuropsychiatric non-motor symptoms burden. These findings highlight the need for an assessment of a wide range of non-motor and motor symptoms when advising and selecting individuals for DBS therapy.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Jost, Stefanie T. UNSPECIFIED UNSPECIFIED UNSPECIFIED Visser-Vandewalle, Veerle UNSPECIFIED UNSPECIFIED UNSPECIFIED Rizos, Alexandra UNSPECIFIED UNSPECIFIED UNSPECIFIED Loehrer, Philipp A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Silverdale, Monty UNSPECIFIED UNSPECIFIED UNSPECIFIED Evans, Julian UNSPECIFIED UNSPECIFIED UNSPECIFIED Samuel, Michael UNSPECIFIED UNSPECIFIED UNSPECIFIED Petry-Schmelzer, Jan Niklas UNSPECIFIED UNSPECIFIED UNSPECIFIED Sauerbier, Anna UNSPECIFIED orcid.org/0000-0003-0966-5933 UNSPECIFIED Gronostay, Alexandra UNSPECIFIED UNSPECIFIED UNSPECIFIED Barbe, Michael T. UNSPECIFIED orcid.org/0000-0003-1149-8054 UNSPECIFIED Fink, Gereon R. UNSPECIFIED orcid.org/0000-0002-8230-1856 UNSPECIFIED Ashkan, Keyoumars UNSPECIFIED UNSPECIFIED UNSPECIFIED Antonini, Angelo UNSPECIFIED orcid.org/0000-0003-1040-2807 UNSPECIFIED Martinez-Martin, Pablo UNSPECIFIED UNSPECIFIED UNSPECIFIED Chaudhuri, K. Ray UNSPECIFIED UNSPECIFIED UNSPECIFIED Timmermann, Lars UNSPECIFIED UNSPECIFIED UNSPECIFIED Dafsari, Haidar S. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-600395
DOI:	10.1038/s41531-021-00174-x
Journal or Publication Title:	npj Parkinsons Dis.
Volume:	7
Number:	1
Date:	2021
Publisher:	NATURE RESEARCH
Place of Publication:	BERLIN
ISSN:	2373-8057
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language DEEP-BRAIN-STIMULATION; NUCLEUS STIMULATION; OUTCOMES; NEUROSTIMULATION; SCORES; TRIAL; SCALE Multiple languages Neurosciences Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/60039