Universität zu Köln

Higuchi, Satoshi ORCID: 0000-0002-7914-8256, Orban, Mathias, Stolz, Lukas, Karam, Nicole ORCID: 0000-0002-3861-6914, Praz, Fabien ORCID: 0000-0001-5416-165X, Kalbacher, Daniel, Ludwig, Sebastian, Braun, Daniel, Naebauer, Michael, Wild, Mirjam G., Neuss, Michael, Butter, Christian, Kassar, Mohammad, Petrescu, Aniela, Pfister, Roman, Iliadis, Christos, Unterhuber, Matthias ORCID: 0000-0002-8175-276X, Park, Sang-Don, Thiele, Holger, Baldus, Stephan, von Bardeleben, Stephan, Schofer, Niklas, Massberg, Steffen, Windecker, Stephan, Lurz, Philipp and Hausleiter, Joerg (2021). Impact of Residual Mitral Regurgitation on Survival After Transcatheter Edge-to-Edge Repair for Secondary Mitral Regurgitation. JACC-Cardiovasc. Interv., 14 (11). S. 1243 - 1254. NEW YORK: ELSEVIER SCIENCE INC. ISSN 1876-7605

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Abstract

Y OBJECTIVES The aim of this study was to assess the impact of residual mitral regurgitation (resMR) on mortality with respect to left ventricular dilatation (LV-Dil) or right ventricular dysfunction (RV-Dys) in patients with secondary mitral regurgitation (SMR) who underwent mitral valve transcatheter edge-to-edge repair (TEER). BACKGROUND The presence of LV-Dil and RV-Dys correlates with advanced stages of heart failure in SMR patients, which may impact the outcome after TEER. METHODS SMR patients in a European multicenter registry were evaluated. Investigated outcomes were 2-year all-cause mortality and improvement in New York Heart Association functional class with respect to MR reduction, LV-Dil (defined as LV end-diastolic volume >= 159 ml), and RV-Dys (defined as tricuspid annular plane systolic excursion-to-systolic pulmonary artery pressure ratio of <0.274 mm/mm Hg). RESULTS Among 809 included patients, resMR <= 1+ was achieved in 546 (67%) patients. Overall estimated 2-year mortality rate was 32%. Post-procedural resMR was significantly associated with mortality (p = 0.031). Although the improvement in New York Heart Association functional class persisted regardless of either LV-Dil or RV-Dys, the beneficial treatment effect of resMR <= 1+ on 2-year mortality was observed only in patients without LV-Dil and RV-Dys (hazard ratio: 1.75; 95% confidence interval: 1.03 to 3.00). CONCLUSIONS Achieving optimal MR reduction by TEER is associated with improved survival in SMR patients, especially if the progress in heart failure is not too advanced. In SMR patients with advanced stages of heart failure, as evidenced by LV-Dil or RV-Dys, the treatment effect of TEER on symptomatic improvement is maintained, but the survival benefit appears to be (C) 2021 by the American College of Cardiology Foundation.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Higuchi, Satoshi UNSPECIFIED orcid.org/0000-0002-7914-8256 UNSPECIFIED Orban, Mathias UNSPECIFIED UNSPECIFIED UNSPECIFIED Stolz, Lukas UNSPECIFIED UNSPECIFIED UNSPECIFIED Karam, Nicole UNSPECIFIED orcid.org/0000-0002-3861-6914 UNSPECIFIED Praz, Fabien UNSPECIFIED orcid.org/0000-0001-5416-165X UNSPECIFIED Kalbacher, Daniel UNSPECIFIED UNSPECIFIED UNSPECIFIED Ludwig, Sebastian UNSPECIFIED UNSPECIFIED UNSPECIFIED Braun, Daniel UNSPECIFIED UNSPECIFIED UNSPECIFIED Naebauer, Michael UNSPECIFIED UNSPECIFIED UNSPECIFIED Wild, Mirjam G. UNSPECIFIED UNSPECIFIED UNSPECIFIED Neuss, Michael UNSPECIFIED UNSPECIFIED UNSPECIFIED Butter, Christian UNSPECIFIED UNSPECIFIED UNSPECIFIED Kassar, Mohammad UNSPECIFIED UNSPECIFIED UNSPECIFIED Petrescu, Aniela UNSPECIFIED UNSPECIFIED UNSPECIFIED Pfister, Roman UNSPECIFIED UNSPECIFIED UNSPECIFIED Iliadis, Christos UNSPECIFIED UNSPECIFIED UNSPECIFIED Unterhuber, Matthias UNSPECIFIED orcid.org/0000-0002-8175-276X UNSPECIFIED Park, Sang-Don UNSPECIFIED UNSPECIFIED UNSPECIFIED Thiele, Holger UNSPECIFIED UNSPECIFIED UNSPECIFIED Baldus, Stephan UNSPECIFIED UNSPECIFIED UNSPECIFIED von Bardeleben, Stephan UNSPECIFIED UNSPECIFIED UNSPECIFIED Schofer, Niklas UNSPECIFIED UNSPECIFIED UNSPECIFIED Massberg, Steffen UNSPECIFIED UNSPECIFIED UNSPECIFIED Windecker, Stephan UNSPECIFIED UNSPECIFIED UNSPECIFIED Lurz, Philipp UNSPECIFIED UNSPECIFIED UNSPECIFIED Hausleiter, Joerg UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-601139
DOI:	10.1016/j.jcin.2021.03.050
Journal or Publication Title:	JACC-Cardiovasc. Interv.
Volume:	14
Number:	11
Page Range:	S. 1243 - 1254
Date:	2021
Publisher:	ELSEVIER SCIENCE INC
Place of Publication:	NEW YORK
ISSN:	1876-7605
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language VALVE REPAIR; EUROPEAN ASSOCIATION; CONTRACTILE FUNCTION; HEART-FAILURE; RISK-FACTOR; RECOMMENDATIONS; SOCIETY; SURGERY Multiple languages Cardiac & Cardiovascular Systems Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/60113