Universität zu Köln

Bucksch, Karolin ORCID: 0000-0003-4586-4032, Zachariae, Silke, Ahadova, Aysel, Aretz, Stefan, Buttner, Reinhard, Goergens, Heike, Holinski-Feder, Elke, Hueneburg, Robert, Kloor, Matthias, Doeberitz, Magnus Knebel, Ladigan-Badura, Swetlana, Moeslein, Gabriela, Morak, Monika, Nattermann, Jacob, Perne, Claudia, Redler, Silke, Schmetz, Ariane, Steinke-Lange, Verena, Surowy, Harald, Vangala, Deepak B., Weitz, Juergen, Loeffler, Markus and Engel, Christoph ORCID: 0000-0002-7247-282X (2022). Adenoma and colorectal cancer risks in Lynch syndrome, Lynch-like syndrome and familial colorectal cancer type X. Int. J. Cancer, 150 (1). S. 56 - 67. HOBOKEN: WILEY. ISSN 1097-0215

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Abstract

Lynch syndrome (LS), Lynch-like syndrome (LLS) and familial colorectal cancer type X (FCCX) are different entities of familial cancer predisposition leading to an increased risk of colorectal cancer (CRC). The aim of this prospective study was to characterise and to compare the risks for adenoma and CRC in these three risk groups. Data was taken from the registry of the German Consortium for Familial Intestinal Cancer. Patients were prospectively followed up in an intensified colonoscopic surveillance programme that included annual examinations. Cumulative risks for adenoma and CRC were calculated separately for LS, LLS and FCCX, and then for males and females. Multivariate Cox regression was used to analyse the independent contributions of risk group, mismatch repair gene (within LS), sex and previous adenoma. The study population comprised 1448 individuals (103 FCCX, 481 LLS and 864 LS). The risks were similar for colorectal adenomas, but different for first and metachronous CRC between the three risk groups. CRC risk was highest in LS, followed by LLS and lowest in FCCX. Male sex and a prevalent adenoma in the index colonoscopy were associated with a higher risk for incident adenoma and CRC. In patients with LS, CRC risks were particularly higher in female MSH2 than MLH1 carriers. Our study may support the development of risk-adapted surveillance policies in LS, LLS and FCCX.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Bucksch, Karolin UNSPECIFIED orcid.org/0000-0003-4586-4032 UNSPECIFIED Zachariae, Silke UNSPECIFIED UNSPECIFIED UNSPECIFIED Ahadova, Aysel UNSPECIFIED UNSPECIFIED UNSPECIFIED Aretz, Stefan UNSPECIFIED UNSPECIFIED UNSPECIFIED Buttner, Reinhard UNSPECIFIED UNSPECIFIED UNSPECIFIED Goergens, Heike UNSPECIFIED UNSPECIFIED UNSPECIFIED Holinski-Feder, Elke UNSPECIFIED UNSPECIFIED UNSPECIFIED Hueneburg, Robert UNSPECIFIED UNSPECIFIED UNSPECIFIED Kloor, Matthias UNSPECIFIED UNSPECIFIED UNSPECIFIED Doeberitz, Magnus Knebel UNSPECIFIED UNSPECIFIED UNSPECIFIED Ladigan-Badura, Swetlana UNSPECIFIED UNSPECIFIED UNSPECIFIED Moeslein, Gabriela UNSPECIFIED UNSPECIFIED UNSPECIFIED Morak, Monika UNSPECIFIED UNSPECIFIED UNSPECIFIED Nattermann, Jacob UNSPECIFIED UNSPECIFIED UNSPECIFIED Perne, Claudia UNSPECIFIED UNSPECIFIED UNSPECIFIED Redler, Silke UNSPECIFIED UNSPECIFIED UNSPECIFIED Schmetz, Ariane UNSPECIFIED UNSPECIFIED UNSPECIFIED Steinke-Lange, Verena UNSPECIFIED UNSPECIFIED UNSPECIFIED Surowy, Harald UNSPECIFIED UNSPECIFIED UNSPECIFIED Vangala, Deepak B. UNSPECIFIED UNSPECIFIED UNSPECIFIED Weitz, Juergen UNSPECIFIED UNSPECIFIED UNSPECIFIED Loeffler, Markus UNSPECIFIED UNSPECIFIED UNSPECIFIED Engel, Christoph UNSPECIFIED orcid.org/0000-0002-7247-282X UNSPECIFIED
URN:	urn:nbn:de:hbz:38-601449
DOI:	10.1002/ijc.33790
Journal or Publication Title:	Int. J. Cancer
Volume:	150
Number:	1
Page Range:	S. 56 - 67
Date:	2022
Publisher:	WILEY
Place of Publication:	HOBOKEN
ISSN:	1097-0215
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language MISMATCH-REPAIR DEFICIENCY; CLINICAL-CRITERIA; GENE-MUTATIONS; GUIDELINES; RECOMMENDATIONS; MANAGEMENT; LIKELIHOOD; REDUCTION; GERMLINE; SOCIETY Multiple languages Oncology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/60144