Zaragori, Timothee, Castello, Angelo, Guedj, Eric, Girard, Antoine, Galldiks, Norbert, Albert, Nathalie L., Lopci, Egesta ORCID: 0000-0001-9732-1094 and Verger, Antoine (2021). Photopenic Defects in Gliomas With Amino-Acid PET and Relative Prognostic Value A Multicentric C-11-Methionine and F-18-FDOPA PET Experience. Clin. Nucl. Med., 46 (1). S. e36 - 2. PHILADELPHIA: LIPPINCOTT WILLIAMS & WILKINS. ISSN 1536-0229

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Abstract

The aim is to explore the concept of photopenic defects in newly diagnosed glioma patients with the 2 widely used C-11-MET and F-18-FDOPA PET amino acid tracers. Thirty-two C-11-MET and 26 F-18-FDOPA PET scans with amino acid PET-negative gliomas were selected in this European multicentric study. Of these gliomas, 16 C-11-MET and 10 F-18-FDOPA PET scans with photopenic defects were identified, exhibiting lower mean tumor-to-background ratio as compared with isometabolic gliomas (P < 0.001). Gliomas with photopenic defects had no different progression-free survival than isometabolic gliomas in the whole population (P = 0.40), but shorter progression-free survival in the subgroup of World Health Organization grade II IDH-mutant astrocytomas (35 vs 68 months; P = 0.047).

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Zaragori, TimotheeUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Castello, AngeloUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Guedj, EricUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Girard, AntoineUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Galldiks, NorbertUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Albert, Nathalie L.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lopci, EgestaUNSPECIFIEDorcid.org/0000-0001-9732-1094UNSPECIFIED
Verger, AntoineUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-602349
DOI: 10.1097/RLU.0000000000003240
Journal or Publication Title: Clin. Nucl. Med.
Volume: 46
Number: 1
Page Range: S. e36 - 2
Date: 2021
Publisher: LIPPINCOTT WILLIAMS & WILKINS
Place of Publication: PHILADELPHIA
ISSN: 1536-0229
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
Radiology, Nuclear Medicine & Medical ImagingMultiple languages
URI: http://kups.ub.uni-koeln.de/id/eprint/60234

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