Universität zu Köln

Franck, Caspar, Zimmermann, Nadja, Goni, Elisabetta, Lippert, Hans, Ridwelski, Karsten, Kruschewski, Martin, Kreuser, Nicole, Lingohr, Philipp, Schildberg, Claus, Vassos, Nikolaos, Waidmann, Oliver, Peitz, Ulrich, Lang, Hauke, Grmminger, Peter P., Bruns, Christiane, Veits, Lothar, Vieth, Michael, Moehler, Markus, Lordick, Florian, Gockel, Ines, Schumacher, Johannes, Malfertheiner, Peter and Venerito, Marino (2021). Different Prevalence of Alarm, Dyspeptic and Reflux Symptoms in Patients with Cardia and Non-cardia Gastric Cancer. J. Gastrointest. Liver Dis., 30 (4). S. 431 - 438. CLUJ-NAPOCA: MEDICAL UNIV PRESS. ISSN 1842-1121

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Abstract

Background & Aims: Symptoms of patients with gastric cancer (GC) are often unspecific and differences in symptoms between patients with cardia and non-cardia GC have been poorly investigated. We aimed to characterize symptoms of patients with cardia and non-cardia GC. Methods: Patients with cardia (Siewert type II and III) and non-cardia GC were recruited in the German multicenter cohort of the Gastric Cancer Research (staR) study between 2013 and 2017. Alarm, dyspeptic and reflux symptoms at the time of presentation were documented using a self-administered questionnaire. Results: A completed self-administered questionnaire was available for 568/759 recruited patients (132 cardia GC, 436 non-cardia GC, male 61%, mean age 64 years). Dyspeptic symptoms were more common in patients with non-cardia GC (69.0 vs. 54.5%, p=0.0024). Cardia GC patients reported more frequently alarm symptoms (69.7 vs. 44.7%, p<0.0001), and were more likely to have Union for International Cancer Control (UICC) stage III-IV (54.1vs. 38.9%, p=0.0034). Especially, dysphagia and weight loss were more common in patients with cardia GC (49.2 vs. 6.4 %, p<0.0001 and 37.1 vs. 25.7%, p=0.02, respectively). No differences between the two groups were observed with respect to reflux symptoms. Patients with alarm symptoms were more likely to have UICC stage III-IV at presentation (69.4 vs. 42.9%, p<0.0001). Conclusions: In clinical practice the symptom pattern at presentation may serve as a hint for tumor localization. Despite the fact that they are common in the general population, dyspeptic symptoms offer a chance for earlier GC detection. Thus, in patients with dyspeptic symptoms who fail empiric approaches, endoscopy should not be delayed.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Franck, Caspar UNSPECIFIED UNSPECIFIED UNSPECIFIED Zimmermann, Nadja UNSPECIFIED UNSPECIFIED UNSPECIFIED Goni, Elisabetta UNSPECIFIED UNSPECIFIED UNSPECIFIED Lippert, Hans UNSPECIFIED UNSPECIFIED UNSPECIFIED Ridwelski, Karsten UNSPECIFIED UNSPECIFIED UNSPECIFIED Kruschewski, Martin UNSPECIFIED UNSPECIFIED UNSPECIFIED Kreuser, Nicole UNSPECIFIED UNSPECIFIED UNSPECIFIED Lingohr, Philipp UNSPECIFIED UNSPECIFIED UNSPECIFIED Schildberg, Claus UNSPECIFIED UNSPECIFIED UNSPECIFIED Vassos, Nikolaos UNSPECIFIED UNSPECIFIED UNSPECIFIED Waidmann, Oliver UNSPECIFIED UNSPECIFIED UNSPECIFIED Peitz, Ulrich UNSPECIFIED UNSPECIFIED UNSPECIFIED Lang, Hauke UNSPECIFIED UNSPECIFIED UNSPECIFIED Grmminger, Peter P. UNSPECIFIED UNSPECIFIED UNSPECIFIED Bruns, Christiane UNSPECIFIED UNSPECIFIED UNSPECIFIED Veits, Lothar UNSPECIFIED UNSPECIFIED UNSPECIFIED Vieth, Michael UNSPECIFIED UNSPECIFIED UNSPECIFIED Moehler, Markus UNSPECIFIED UNSPECIFIED UNSPECIFIED Lordick, Florian UNSPECIFIED UNSPECIFIED UNSPECIFIED Gockel, Ines UNSPECIFIED UNSPECIFIED UNSPECIFIED Schumacher, Johannes UNSPECIFIED UNSPECIFIED UNSPECIFIED Malfertheiner, Peter UNSPECIFIED UNSPECIFIED UNSPECIFIED Venerito, Marino UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-602852
DOI:	10.15403/jgld-3795
Journal or Publication Title:	J. Gastrointest. Liver Dis.
Volume:	30
Number:	4
Page Range:	S. 431 - 438
Date:	2021
Publisher:	MEDICAL UNIV PRESS
Place of Publication:	CLUJ-NAPOCA
ISSN:	1842-1121
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language STOMACH-CANCER; RISK; ADENOCARCINOMA; DIAGNOSIS; FEATURES; SALT; EPIDEMIOLOGY; ASSOCIATION; CONSUMPTION; ESOPHAGEAL Multiple languages Gastroenterology & Hepatology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/60285