Islam, Md Rezaul, Kaurani, Lalit, Berulava, Tea, Heilbronner, Urs ORCID: 0000-0001-7135-762X, Budde, Monika, Centeno, Tonatiuh Pena, Elerdashvili, Vakthang, Zafieriou, Maria-Patapia, Benito, Eva, Sertel, Sinem M., Goldberg, Maria, Senner, Fanny, Kalman, Janos L., Burkhardt, Susanne, Oepen, Anne Sophie, Sakib, Mohammad Sadman, Kerimolgu, Cemil, Wirths, Oliver ORCID: 0000-0002-4115-0334, Bickeboeller, Heike, Bartels, Claudia, Brosseron, Frederic, Buerger, Katharina, Cosma, Nicoleta-Carmen, Fliessbach, Klaus, Heneka, Michael T., Janowitz, Daniel, Kilimann, Ingo, Kleinedam, Luca, Laske, Christoph, Metzger, Coraline D., Munk, Matthias H., Perneczky, Robert, Peters, Oliver, Priller, Josef, Rauchmann, Boris S., Roy, Nina, Schneider, Anja, Spottke, Annika, Spruth, Eike J., Teipel, Stefan, Tscheuschler, Maike, Wagner, Michael, Wiltfang, Jens, Duzel, Emrah, Jessen, Frank, Rizzoli, Silvio O., Zimmermann, Wolfram-Hubertus, Schulze, Thomas G., Falkai, Peter, Sananbenesi, Farahnaz and Fischer, Andre (2021). A microRNA signature that correlates with cognition and is a target against cognitive decline. EMBO Mol. Med., 13 (11). HOBOKEN: WILEY. ISSN 1757-4684

Full text not available from this repository.

Abstract

While some individuals age without pathological memory impairments, others develop age-associated cognitive diseases. Since changes in cognitive function develop slowly over time in these patients, they are often diagnosed at an advanced stage of molecular pathology, a time point when causative treatments fail. Thus, there is great need for the identification of inexpensive and minimal invasive approaches that could be used for screening with the aim to identify individuals at risk for cognitive decline that can then undergo further diagnostics and eventually stratified therapies. In this study, we use an integrative approach combining the analysis of human data and mechanistic studies in model systems to identify a circulating 3-microRNA signature that reflects key processes linked to neural homeostasis and inform about cognitive status. We furthermore provide evidence that expression changes in this signature represent multiple mechanisms deregulated in the aging and diseased brain and are a suitable target for RNA therapeutics.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Islam, Md RezaulUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kaurani, LalitUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Berulava, TeaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Heilbronner, UrsUNSPECIFIEDorcid.org/0000-0001-7135-762XUNSPECIFIED
Budde, MonikaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Centeno, Tonatiuh PenaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Elerdashvili, VakthangUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Zafieriou, Maria-PatapiaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Benito, EvaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Sertel, Sinem M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Goldberg, MariaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Senner, FannyUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kalman, Janos L.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Burkhardt, SusanneUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Oepen, Anne SophieUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Sakib, Mohammad SadmanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kerimolgu, CemilUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Wirths, OliverUNSPECIFIEDorcid.org/0000-0002-4115-0334UNSPECIFIED
Bickeboeller, HeikeUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bartels, ClaudiaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Brosseron, FredericUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Buerger, KatharinaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Cosma, Nicoleta-CarmenUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Fliessbach, KlausUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Heneka, Michael T.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Janowitz, DanielUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kilimann, IngoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kleinedam, LucaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Laske, ChristophUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Metzger, Coraline D.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Munk, Matthias H.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Perneczky, RobertUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Peters, OliverUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Priller, JosefUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Rauchmann, Boris S.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Roy, NinaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schneider, AnjaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Spottke, AnnikaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Spruth, Eike J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Teipel, StefanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Tscheuschler, MaikeUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Wagner, MichaelUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Wiltfang, JensUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Duzel, EmrahUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Jessen, FrankUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Rizzoli, Silvio O.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Zimmermann, Wolfram-HubertusUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schulze, Thomas G.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Falkai, PeterUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Sananbenesi, FarahnazUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Fischer, AndreUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-603550
DOI: 10.15252/emmm.202013659
Journal or Publication Title: EMBO Mol. Med.
Volume: 13
Number: 11
Date: 2021
Publisher: WILEY
Place of Publication: HOBOKEN
ISSN: 1757-4684
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
PRECLINICAL ALZHEIMERS-DISEASE; GENE-EXPRESSION; CIRCULATING MICRORNAS; AGE; BRAIN; MEMORY; BIOMARKERS; MIRNAS; BLOOD; MICEMultiple languages
Medicine, Research & ExperimentalMultiple languages
URI: http://kups.ub.uni-koeln.de/id/eprint/60355

Downloads

Downloads per month over past year

Altmetric

Export

Actions (login required)

View Item View Item