Universität zu Köln

Dickens, Alex M., Sen, Partho ORCID: 0000-0003-0475-2763, Kempton, Matthew J., Barrantes-Vidal, Neus ORCID: 0000-0002-8671-1238, Iyegbe, Conrad, Nordentoft, Merete, Pollak, Thomas ORCID: 0000-0002-6171-0810, Riecher-Rossler, Anita, Ruhrmann, Stephan ORCID: 0000-0002-6022-2364, Sachs, Gabriele ORCID: 0000-0002-8359-9877, Bressan, Rodrigo, Krebs, Marie-Odile ORCID: 0000-0002-4715-9890, Amminger, G. Paul, de Haan, Lieuwe, van der Gaag, Mark ORCID: 0000-0002-3525-6415, Valmaggia, Lucia ORCID: 0000-0001-6099-8464, Hyotylainen, Tuulia, Oresic, Matej ORCID: 0000-0002-2856-9165 and McGuire, Philip ORCID: 0000-0003-4381-0532 (2021). Dysregulated Lipid Metabolism Precedes Onset of Psychosis. Biol. Psychiatry, 89 (3). S. 288 - 298. NEW YORK: ELSEVIER SCIENCE INC. ISSN 1873-2402

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Abstract

BACKGROUND: A key clinical challenge in the management of individuals at clinical high risk for psychosis (CHR) is that it is difficult to predict their future clinical outcomes. Here, we investigated if the levels of circulating molecular lipids are related to adverse clinical outcomes in this group. METHODS: Serum lipidomic analysis was performed in 263 CHR individuals and 51 healthy control subjects, who were then clinically monitored for up to 5 years. Machine learning was used to identify lipid profiles that discriminated between CHR and control subjects, and between subgroups of CHR subjects with distinct clinical outcomes. RESULTS: At baseline, compared with control subjects, CHR subjects (independent of outcome) had higher levels of triacylglycerols with a low acyl carbon number and a double bond count, as well as higher levels of lipids in general. CHR subjects who subsequently developed psychosis (n = 50) were distinguished from those that did not (n = 213) on the basis of lipid profile at baseline using a model with an area under the receiver operating curve of 0.81 (95% confidence interval = 0.69-0.93). CHR subjects who became psychotic had lower levels of ether phospholipids than CHR individuals who did not (p < .01). CONCLUSIONS: Collectively, these data suggest that lipidomic abnormalities predate the onset of psychosis and that blood lipidomic measures may be useful in predicting which CHR individuals are most likely to develop psychosis.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Dickens, Alex M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Sen, Partho UNSPECIFIED orcid.org/0000-0003-0475-2763 UNSPECIFIED Kempton, Matthew J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Barrantes-Vidal, Neus UNSPECIFIED orcid.org/0000-0002-8671-1238 UNSPECIFIED Iyegbe, Conrad UNSPECIFIED UNSPECIFIED UNSPECIFIED Nordentoft, Merete UNSPECIFIED UNSPECIFIED UNSPECIFIED Pollak, Thomas UNSPECIFIED orcid.org/0000-0002-6171-0810 UNSPECIFIED Riecher-Rossler, Anita UNSPECIFIED UNSPECIFIED UNSPECIFIED Ruhrmann, Stephan UNSPECIFIED orcid.org/0000-0002-6022-2364 UNSPECIFIED Sachs, Gabriele UNSPECIFIED orcid.org/0000-0002-8359-9877 UNSPECIFIED Bressan, Rodrigo UNSPECIFIED UNSPECIFIED UNSPECIFIED Krebs, Marie-Odile UNSPECIFIED orcid.org/0000-0002-4715-9890 UNSPECIFIED Amminger, G. Paul UNSPECIFIED UNSPECIFIED UNSPECIFIED de Haan, Lieuwe UNSPECIFIED UNSPECIFIED UNSPECIFIED van der Gaag, Mark UNSPECIFIED orcid.org/0000-0002-3525-6415 UNSPECIFIED Valmaggia, Lucia UNSPECIFIED orcid.org/0000-0001-6099-8464 UNSPECIFIED Hyotylainen, Tuulia UNSPECIFIED UNSPECIFIED UNSPECIFIED Oresic, Matej UNSPECIFIED orcid.org/0000-0002-2856-9165 UNSPECIFIED McGuire, Philip UNSPECIFIED orcid.org/0000-0003-4381-0532 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-603572
DOI:	10.1016/j.biopsych.2020.07.012
Journal or Publication Title:	Biol. Psychiatry
Volume:	89
Number:	3
Page Range:	S. 288 - 298
Date:	2021
Publisher:	ELSEVIER SCIENCE INC
Place of Publication:	NEW YORK
ISSN:	1873-2402
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language FATTY-ACIDS; RISK; SCHIZOPHRENIA; SPHINGOMYELIN; PLASMALOGENS; INDIVIDUALS; MECHANISMS; DISEASE Multiple languages Neurosciences; Psychiatry Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/60357