Song, Mengmeng, Scheifele, Maximilian, Barthel, Henryk, van Eimeren, Thilo ORCID: 0000-0002-6951-2325, Beyer, Leonie, Marek, Ken, Eckenweber, Florian, Palleis, Carla, Kaiser, Lena, Finze, Anika, Kern, Maike, Nitschmann, Alexander, Biechele, Gloria, Katzdobler, Sabrina, Bischof, Gerard, Hammes, Jochen, Jessen, Frank, Saur, Dorothee ORCID: 0000-0002-1808-0913, Schroeter, Matthias L., Rumpf, Jost-Julian, Rullmann, Michael ORCID: 0000-0002-2683-9432, Schildan, Andreas, Patt, Marianne, Neumaier, Bernd, Stephens, Andrew W., Rauchmann, Boris-Stephan, Perneczky, Robert, Levin, Johannes ORCID: 0000-0001-5092-4306, Classen, Joseph, Hoeglinger, Guenter U., Bartenstein, Peter, Boening, Guido, Ziegler, Sibylle, Villemagne, Victor, Drzezga, Alexander ORCID: 0000-0001-6018-716X, Seibyl, John, Sabri, Osama and Brendel, Matthias (2021). Feasibility of short imaging protocols for [F-18]PI-2620 tau-PET in progressive supranuclear palsy. Eur. J. Nucl. Med. Mol. Imaging, 48 (12). S. 3872 - 3886. NEW YORK: SPRINGER. ISSN 1619-7089

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Abstract

Purpose Dynamic 60-min positron emission tomography (PET) imaging with the novel tau radiotracer [F-18]PI-2620 facilitated accurate discrimination between patients with progressive supranuclear palsy (PSP) and healthy controls (HCs). This study investigated if truncated acquisition and static time windows can be used for [F-18]PI-2620 tau-PET imaging of PSP. Methods Thirty-seven patients with PSP Richardson syndrome (PSP-RS) were evaluated together with ten HCs. [F-18]PI-2620 PET was performed by a dynamic 60-min scan. Distribution volume ratios (DVRs) were calculated using full and truncated scan durations (0-60, 0-50, 0-40, 0-30, and 0-20 min p.i.). Standardized uptake value ratios (SUVrs) were obtained 20-40, 30-50, and 40-60 min p.i.. All DVR and SUVr data were compared with regard to their potential to discriminate patients with PSP-RS from HCs in predefined subcortical and cortical target regions (effect size, area under the curve (AUC), multi-region classifier). Results 0-50 and 0-40 DVR showed equivalent effect sizes as 0-60 DVR (averaged Cohen's d: 1.22 and 1.16 vs. 1.26), whereas the performance dropped for 0-30 or 0-20 DVR. The 20-40 SUVr indicated the best performance of all static acquisition windows (averaged Cohen's d: 0.99). The globus pallidus internus discriminated patients with PSP-RS and HCs at a similarly high level for 0-60 DVR (AUC: 0.96), 0-40 DVR (AUC: 0.96), and 20-40 SUVr (AUC: 0.94). The multi-region classifier sensitivity of these time windows was consistently 86%. Conclusion Truncated and static imaging windows can be used for [F-18]PI-2620 PET imaging of PSP. 0-40 min dynamic scanning offers the best balance between accuracy and economic scanning.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Song, MengmengUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Scheifele, MaximilianUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Barthel, HenrykUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
van Eimeren, ThiloUNSPECIFIEDorcid.org/0000-0002-6951-2325UNSPECIFIED
Beyer, LeonieUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Marek, KenUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Eckenweber, FlorianUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Palleis, CarlaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kaiser, LenaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Finze, AnikaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kern, MaikeUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Nitschmann, AlexanderUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Biechele, GloriaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Katzdobler, SabrinaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bischof, GerardUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hammes, JochenUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Jessen, FrankUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Saur, DorotheeUNSPECIFIEDorcid.org/0000-0002-1808-0913UNSPECIFIED
Schroeter, Matthias L.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Rumpf, Jost-JulianUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Rullmann, MichaelUNSPECIFIEDorcid.org/0000-0002-2683-9432UNSPECIFIED
Schildan, AndreasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Patt, MarianneUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Neumaier, BerndUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Stephens, Andrew W.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Rauchmann, Boris-StephanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Perneczky, RobertUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Levin, JohannesUNSPECIFIEDorcid.org/0000-0001-5092-4306UNSPECIFIED
Classen, JosephUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hoeglinger, Guenter U.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bartenstein, PeterUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Boening, GuidoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ziegler, SibylleUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Villemagne, VictorUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Drzezga, AlexanderUNSPECIFIEDorcid.org/0000-0001-6018-716XUNSPECIFIED
Seibyl, JohnUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Sabri, OsamaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Brendel, MatthiasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-604404
DOI: 10.1007/s00259-021-05391-3
Journal or Publication Title: Eur. J. Nucl. Med. Mol. Imaging
Volume: 48
Number: 12
Page Range: S. 3872 - 3886
Date: 2021
Publisher: SPRINGER
Place of Publication: NEW YORK
ISSN: 1619-7089
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
MOUSE MODEL; DISEASE PROGRESSION; PATHOLOGY; BRAINMultiple languages
Radiology, Nuclear Medicine & Medical ImagingMultiple languages
URI: http://kups.ub.uni-koeln.de/id/eprint/60440

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