Charisse, Daniel, Erus, Guray ORCID: 0000-0001-6633-4861, Pomponio, Raymond, Gorges, Martin, Schmidt, Nele, Schneider, Christine, Liepelt-Scarfone, Inga, Riedel, Oliver, Reetz, Kathrin, Schulz, Joerg B., Berg, Daniela, Storch, Alexander, Witt, Karsten, Dodel, Richard, Kalbe, Elke, Kassubek, Jan ORCID: 0000-0002-7106-9270, Hilker-Roggendorf, Rudiger and Baudrexel, Simon (2022). Brain age and Alzheimer's-like atrophy are domain-specific predictors of cognitive impairment in Parkinson's disease. Neurobiol. Aging, 109. S. 31 - 43. NEW YORK: ELSEVIER SCIENCE INC. ISSN 1558-1497

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Abstract

Recently, it was shown that patients with Parkinson's disease (PD) who exhibit an Alzheimer's disease (AD)-like pattern of brain atrophy are at greater risk for future cognitive decline. This study aimed to investigate whether this association is domain-specific and whether atrophy associated with brain aging also relates to cognitive impairment in PD. SPARE-AD, an MRI index capturing AD-like atrophy, and atrophy-based estimates of brain age were computed from longitudinal structural imaging data of 178 PD patients and 84 healthy subjects from the LANDSCAPE cohort. All patients underwent an extensive neuropsychological test battery. Patients diagnosed with mild cognitive impairment or dementia were found to have higher SPARE-AD scores as compared to patients with normal cognition and healthy controls. All patient groups showed increased brain age. SPARE-AD predicted impairment in memory, language and executive functions, whereas advanced brain age was associated with deficits in attention and working memory. Data suggest that SPARE-AD and brain age are differentially related to domain-specific cognitive decline in PD. The underlying pathomechanisms remain to be determined. (c) 2021 Elsevier Inc. All rights reserved.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Charisse, DanielUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Erus, GurayUNSPECIFIEDorcid.org/0000-0001-6633-4861UNSPECIFIED
Pomponio, RaymondUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Gorges, MartinUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schmidt, NeleUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schneider, ChristineUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Liepelt-Scarfone, IngaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Riedel, OliverUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Reetz, KathrinUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schulz, Joerg B.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Berg, DanielaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Storch, AlexanderUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Witt, KarstenUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Dodel, RichardUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kalbe, ElkeUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kassubek, JanUNSPECIFIEDorcid.org/0000-0002-7106-9270UNSPECIFIED
Hilker-Roggendorf, RudigerUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Baudrexel, SimonUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-605136
DOI: 10.1016/j.neurobiolaging.2021.08.020
Journal or Publication Title: Neurobiol. Aging
Volume: 109
Page Range: S. 31 - 43
Date: 2022
Publisher: ELSEVIER SCIENCE INC
Place of Publication: NEW YORK
ISSN: 1558-1497
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
WHITE-MATTER HYPERINTENSITIES; DOPAMINERGIC DEFICITS; DIAGNOSTIC-CRITERIA; EXECUTIVE FUNCTION; CSF BIOMARKERS; TASK-FORCE; DEMENTIA; MILD; DECLINE; MRIMultiple languages
Geriatrics & Gerontology; NeurosciencesMultiple languages
URI: http://kups.ub.uni-koeln.de/id/eprint/60513

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