Ophey, Anja ORCID: 0000-0001-5858-7762, Wolfsgruber, Steffen, Roeske, Sandra, Polcher, Alexandra, Spottke, Annika, Frolich, Lutz, Hull, Michael, Jessen, Frank, Kornhuber, Johannes, Maier, Wolfgang, Peters, Oliver, Ramirez, Alfredo ORCID: 0000-0003-4991-763X, Wiltfang, Jens, Liepelt-Scarfone, Inga, Becker, Sara ORCID: 0000-0002-4595-580X, Berg, Daniela, Schulz, Jorg B., Reetz, Kathrin, Wojtala, Jennifer, Kassubek, Jan ORCID: 0000-0002-7106-9270, Storch, Alexander, Balzer-Geldsetzer, Monika, Hilker-Roggendorf, Rudiger, Witt, Karsten, Mollenhauer, Brit, Trenkwalder, Claudia, Wittchen, Hans-Ullrich, Riedel, Oliver, Dodel, Richard, Wagner, Michael ORCID: 0000-0003-2589-6440 and Kalbe, Elke (2021). Cognitive profiles of patients with mild cognitive impairment due to Alzheimer's versus Parkinson's disease defined using a base rate approach: Implications for neuropsychological assessments. Alzheimers Dement.-Diagn. Assess. Dis. Monit., 13 (1). HOBOKEN: WILEY. ISSN 2352-8729

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Abstract

Introduction Large studies on cognitive profiles of patients with mild cognitive impairment (MCI) due to Alzheimer's disease (AD-MCI) compared to Parkinson's disease (PD-MCI) are rare. Methods Data from two multicenter cohort studies in AD and PD were merged using a unified base rate approach for the MCI diagnosis. Cognitive profiles were compared using scores derived from the Consortium to Establish a Registry for Alzheimer's Disease battery. Results Patients with AD-MCI showed lower standardized scores on all memory test scores and a language test. Patients with PD-MCI showed lower standardized scores in a set-shifting measure as an executive task. A cross-validated logistic regression with test scores as predictors was able to classify 72% of patients correctly to AD-MCI versus PD-MCI. Discussion The applied test battery successfully discriminated between AD-MCI and PD-MCI. Neuropsychological test batteries in clinical practice should always include a broad spectrum of cognitive domains to capture any cognitive changes.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Ophey, AnjaUNSPECIFIEDorcid.org/0000-0001-5858-7762UNSPECIFIED
Wolfsgruber, SteffenUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Roeske, SandraUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Polcher, AlexandraUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Spottke, AnnikaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Frolich, LutzUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hull, MichaelUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Jessen, FrankUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kornhuber, JohannesUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Maier, WolfgangUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Peters, OliverUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ramirez, AlfredoUNSPECIFIEDorcid.org/0000-0003-4991-763XUNSPECIFIED
Wiltfang, JensUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Liepelt-Scarfone, IngaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Becker, SaraUNSPECIFIEDorcid.org/0000-0002-4595-580XUNSPECIFIED
Berg, DanielaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schulz, Jorg B.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Reetz, KathrinUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Wojtala, JenniferUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kassubek, JanUNSPECIFIEDorcid.org/0000-0002-7106-9270UNSPECIFIED
Storch, AlexanderUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Balzer-Geldsetzer, MonikaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hilker-Roggendorf, RudigerUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Witt, KarstenUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Mollenhauer, BritUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Trenkwalder, ClaudiaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Wittchen, Hans-UllrichUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Riedel, OliverUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Dodel, RichardUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Wagner, MichaelUNSPECIFIEDorcid.org/0000-0003-2589-6440UNSPECIFIED
Kalbe, ElkeUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-606191
DOI: 10.1002/dad2.12223
Journal or Publication Title: Alzheimers Dement.-Diagn. Assess. Dis. Monit.
Volume: 13
Number: 1
Date: 2021
Publisher: WILEY
Place of Publication: HOBOKEN
ISSN: 2352-8729
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
HEALTHY OLDER-ADULTS; ASSESSMENT BATTERY; MEMORY SCORES; DEMENTIA; CERAD; DIAGNOSIS; ACCURACY; SCALE; CONSORTIUM; ESTABLISHMultiple languages
Clinical Neurology; NeurosciencesMultiple languages
URI: http://kups.ub.uni-koeln.de/id/eprint/60619

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