Roth, Mathias, Holtmann, Christoph, Daas, Loay, Kakkassery, Vinodh, Kurzai, Oliver, Geerling, Gerd, Baeurle, Sebastian, Bayoudh, Wesal, Bruecher, Viktoria, Cvetkova-Fischer, Nadezhda, Blak, Matthias Dias, Bornstein, Agnes, Fischer, Charlotte, Fuest, Matthias, Grisanti, Salvatore, Herwig-Carl, Martina C., Kroll, Sandra, Lenk, Janine, Lommatzsch, Claudia, MacKenzie, Colin R., Matthaei, Mario, Mehlan, Juliane, Messmer, Elisabeth M., Mueller, Violetta, Pawlik, Vera, Ranjbar, Mahdy, Renner-Wilde, Anna, Rickmann, Annekatrin, Saeger, Mark, Schargus, Marc, Schwarz, Luisa, Seitz, Berthold, Steindor, Friedrich, Unterlauf, Jan Darius, Viestenz, Arne, von Lilienfeld-Toal, Marie and Walther, Grit (2021). Results From the German Fungal Keratitis Registry: Significant Differences Between Cases With and Without a History of Contact Lens Use. Cornea, 40 (11). S. 1453 - 1462. PHILADELPHIA: LIPPINCOTT WILLIAMS & WILKINS. ISSN 1536-4798

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Abstract

Purpose: Fungal keratitis (FK) is a serious ophthalmic disease with a potentially devastating outcome that seems to be increasing in recent years. The use of contact lenses (CLs) was evaluated as a risk factor for FK to determine possible differences in course and outcome. Methods: Data from 173 cases reported in the German FK registry until August 2019 were evaluated regarding CL behavior, other ophthalmological and general risk factors, age, sex, identified pathogens, conservative and surgical therapy, visual acuity, and findings at admission and follow-up. Results: One hundred seventy-four eyes from 173 patients between 2000 and 2019 were included [64.4% women, median age 54 (39; 72) years]; 49.7% wore CL, of which 81.3% were soft CL, and 50.3% had no history of contact lens use (NCL). CL users were significantly more often women and otherwise healthy (CL: 80.2% vs. NCL: 48.9%; P < 0.0001). The spectrum of pathogens among CL users showed a significantly higher proportion of infections with filamentous pathogens, in particular Fusarium sp. (total filament: CL 69.8% vs. NCL 27.3%; P = 0.0001; Fusarium sp.: CL 50.0% vs. NCL 14.8%; P < 0.0001). Overall, 54.6% required keratoplasty and 8.6% enucleation. Conclusions: CLS are the most important risk factor for FK in Germany. With CLs, typically, the infection is caused by molds, and patients are comparably younger and otherwise healthy. Often, extensive surgery is needed. To evaluate changes in the pathogen and resistance spectrum and to further monitor possible CL-related risk factors, a consistent collection of data remains paramount.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Roth, MathiasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Holtmann, ChristophUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Daas, LoayUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kakkassery, VinodhUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kurzai, OliverUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Geerling, GerdUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Baeurle, SebastianUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bayoudh, WesalUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bruecher, ViktoriaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Cvetkova-Fischer, NadezhdaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Blak, Matthias DiasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bornstein, AgnesUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Fischer, CharlotteUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Fuest, MatthiasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Grisanti, SalvatoreUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Herwig-Carl, Martina C.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kroll, SandraUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lenk, JanineUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lommatzsch, ClaudiaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
MacKenzie, Colin R.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Matthaei, MarioUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Mehlan, JulianeUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Messmer, Elisabeth M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Mueller, ViolettaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Pawlik, VeraUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ranjbar, MahdyUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Renner-Wilde, AnnaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Rickmann, AnnekatrinUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Saeger, MarkUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schargus, MarcUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schwarz, LuisaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Seitz, BertholdUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Steindor, FriedrichUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Unterlauf, Jan DariusUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Viestenz, ArneUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
von Lilienfeld-Toal, MarieUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Walther, GritUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-606467
DOI: 10.1097/ICO.0000000000002705
Journal or Publication Title: Cornea
Volume: 40
Number: 11
Page Range: S. 1453 - 1462
Date: 2021
Publisher: LIPPINCOTT WILLIAMS & WILKINS
Place of Publication: PHILADELPHIA
ISSN: 1536-4798
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
CLINICAL CHARACTERISTICS; BACTERIAL; FUSARIUM; LONDONMultiple languages
OphthalmologyMultiple languages
URI: http://kups.ub.uni-koeln.de/id/eprint/60646

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