Park, Se Eun, Pak, Gi Deok, Panzner, Ursula, Espinoza, Ligia Maria Cruz, von Kalckreuth, Vera, Im, Justin, Mogeni, Ondari D., Schutt-Gerowitt, Heidi, Crump, John A., Breiman, Robert F., Adu-Sarkodie, Yaw, Owusu-Dabo, Ellis, Rakotozandrindrainy, Raphael, Soura, Abdramane Bassiahi, Aseffa, Abraham ORCID: 0000-0002-8028-1150, Gasmelseed, Nagla, Sooka, Arvinda, Keddy, Karen H., May, Jurgen, Aaby, Peter, Biggs, Holly M., Hertz, Julian T., Montgomery, Joel M., Cosmas, Leonard, Olack, Beatrice, Fields, Barry, Sarpong, Nimako, Razafindrabe, Tsiriniaina Jean Luco, Raminosoa, Tiana Mirana, Kabore, Leon Parfait, Sampo, Emmanuel, Teferi, Mekonnen, Yeshitela, Biruk, El Tayeb, Muna Ahmed, Krumkamp, Ralf, Dekker, Denise Myriam, Jaeger, Anna, Tall, Adama, Gassama, Amy, Niang, Aissatou, Bjerregaard-Andersen, Morten ORCID: 0000-0002-4128-5714, Lofberg, Sandra Valborg, Deerin, Jessica Fung, Park, Jin Kyung, Konings, Frank, Carey, Megan E., Van Puyvelde, Sandra, Ali, Mohammad, Clemens, John, Dougan, Gordon, Baker, Stephen and Marks, Florian ORCID: 0000-0002-6043-7170 (2021). The genomic epidemiology of multi-drug resistant invasive non-typhoidal Salmonella in selected sub-Saharan African countries. BMJ Glob. Health, 6 (8). LONDON: BMJ PUBLISHING GROUP. ISSN 2059-7908

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Abstract

Background Invasive non-typhoidal Salmonella (iNTS) is one of the leading causes of bacteraemia in sub-Saharan Africa. We aimed to provide a better understanding of the genetic characteristics and transmission patterns associated with multi-drug resistant (MDR) iNTS serovars across the continent. Methods A total of 166 iNTS isolates collected from a multi-centre surveillance in 10 African countries (2010-2014) and a fever study in Ghana (2007-2009) were genome sequenced to investigate the geographical distribution, antimicrobial genetic determinants and population structure of iNTS serotypes-genotypes. Phylogenetic analyses were conducted in the context of the existing genomic frameworks for various iNTS serovars. Population-based incidence of MDR-iNTS disease was estimated in each study site. Results Salmonella Typhimurium sequence-type (ST) 313 and Salmonella Enteritidis ST11 were predominant, and both exhibited high frequencies of MDR; Salmonella Dublin ST10 was identified in West Africa only. Mutations in the gyrA gene (fluoroquinolone resistance) were identified in S. Enteritidis and S. Typhimurium in Ghana; an ST313 isolate carrying bla(CTX-M-15) was found in Kenya. International transmission of MDR ST313 (lineage II) and MDR ST11 (West African clade) was observed between Ghana and neighbouring West African countries. The incidence of MDR-iNTS disease exceeded 100/100 000 person-years-of-observation in children aged Conclusions We identified the circulation of multiple MDR iNTS serovar STs in the sampled sub-Saharan African countries. Investment in the development and deployment of iNTS vaccines coupled with intensified antimicrobial resistance surveillance are essential to limit the impact of these pathogens in Africa.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Park, Se EunUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Pak, Gi DeokUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Panzner, UrsulaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Espinoza, Ligia Maria CruzUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
von Kalckreuth, VeraUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Im, JustinUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Mogeni, Ondari D.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schutt-Gerowitt, HeidiUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Crump, John A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Breiman, Robert F.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Adu-Sarkodie, YawUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Owusu-Dabo, EllisUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Rakotozandrindrainy, RaphaelUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Soura, Abdramane BassiahiUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Aseffa, AbrahamUNSPECIFIEDorcid.org/0000-0002-8028-1150UNSPECIFIED
Gasmelseed, NaglaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Sooka, ArvindaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Keddy, Karen H.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
May, JurgenUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Aaby, PeterUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Biggs, Holly M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hertz, Julian T.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Montgomery, Joel M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Cosmas, LeonardUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Olack, BeatriceUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Fields, BarryUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Sarpong, NimakoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Razafindrabe, Tsiriniaina Jean LucoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Raminosoa, Tiana MiranaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kabore, Leon ParfaitUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Sampo, EmmanuelUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Teferi, MekonnenUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Yeshitela, BirukUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
El Tayeb, Muna AhmedUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Krumkamp, RalfUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Dekker, Denise MyriamUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Jaeger, AnnaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Tall, AdamaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Gassama, AmyUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Niang, AissatouUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bjerregaard-Andersen, MortenUNSPECIFIEDorcid.org/0000-0002-4128-5714UNSPECIFIED
Lofberg, Sandra ValborgUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Deerin, Jessica FungUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Park, Jin KyungUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Konings, FrankUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Carey, Megan E.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Van Puyvelde, SandraUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ali, MohammadUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Clemens, JohnUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Dougan, GordonUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Baker, StephenUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Marks, FlorianUNSPECIFIEDorcid.org/0000-0002-6043-7170UNSPECIFIED
URN: urn:nbn:de:hbz:38-607053
DOI: 10.1136/bmjgh-2021-005659
Journal or Publication Title: BMJ Glob. Health
Volume: 6
Number: 8
Date: 2021
Publisher: BMJ PUBLISHING GROUP
Place of Publication: LONDON
ISSN: 2059-7908
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
BLOOD-STREAM INFECTION; ANTIMICROBIAL RESISTANCE; FEVER SURVEILLANCE; CHILDREN; DISEASE; ENTERITIDIS; BACTEREMIA; NIGERIA; TOOL; SUSCEPTIBILITYMultiple languages
Public, Environmental & Occupational HealthMultiple languages
URI: http://kups.ub.uni-koeln.de/id/eprint/60705

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