Caby, Fabienne, Guiguet, Marguerite, Weiss, Laurence, Winston, Alan, Miro, Jose M., Konopnicki, Deborah, Le Moing, Vincent, Bonnet, Fabrice, Reiss, Peter, Mussini, Cristina ORCID: 0000-0002-6615-4198, Poizot-Martin, Isabelle, Taylor, Ninon, Skoutelis, Athanasios, Meyer, Laurence, Goujard, Cecile, Bartmeyer, Barbara, Boesecke, Christoph, Antinori, Andrea, Quiros-Roldan, Eugenia, Wittkop, Linda, Frederiksen, Casper, Castagna, Antonella, Thurnheer, Maria Christine, Svedhem, Veronica, Jose, Sophie, Costagliola, Dominique ORCID: 0000-0003-0765-0869, Mary-Krause, Murielle and Grabar, Sophie (2021). CD4/CD8 Ratio and the Risk of Kaposi Sarcoma or Non-Hodgkin Lymphoma in the Context of Efficiently Treated Human Immunodeficiency Virus (HIV) Infection: A Collaborative Analysis of 20 European Cohort Studies. Clin. Infect. Dis., 73 (1). S. 50 - 60. CARY: OXFORD UNIV PRESS INC. ISSN 1537-6591

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Abstract

Background. A persistently low CD4/CD8 ratio has been reported to inversely correlate with the risk of non-AIDS defining cancer in people living with human immunodeficiency virus (HIV; PLWH) efficiently treated by combination antiretroviral therapy (cART). We evaluated the impact of the CD4/CD8 ratio on the risk of Kaposi sarcoma (KS) or non-Hodgkin lymphoma (NHL), still among the most frequent cancers in treated PLWH. Methods. PLWH from the Collaboration of Observational HIV Epidemiological Research Europe (COHERE) were included if they achieved virological control (viral load <= 500 copies/mL) within 9 months following cART and without previous KS/LNH diagnosis. Cox models were used to identify factors associated with KS or NHL risk, in all participants and those with CD4 >= 500/mm(3) at virological control. We analyzed the CD4/CD8 ratio, CD4 count and CD8 count as time-dependent variables, using spline transformations. Results. We included 56 708 PLWH, enrolled between 2000 and 2014. At virological control, the median (interquartile range [IQR]) CD4 count, CD8 count, and CD4/CD8 ratio were 414 (296-552)/mm(3), 936 (670-1304)/mm(3), and 0.43 (0.28-0.65), respectively. Overall, 221 KS and 187 NHL were diagnosed 9 (2-37) and 18 (7-42) months after virological control. Low CD4/CD8 ratios were associated with KS risk (hazard ratio [HR] = 2.02 [95% confidence interval {CI} = 1.23-3.31]) when comparing CD4/CD8 = 0.3 to CD4/CD8 = 1) but not with NHL risk. High CD8 counts were associated with higher NHL risk (HR = 3.14 [95% CI = 1.58-6.22]) when comparing CD8 = 3000/mm(3) to CD8 = 1000/mm(3)). Similar results with increased associations were found in PLWH with CD4 >= 500/mm(3) at virological control (HR = 3.27 [95% CI = 1.60-6.56] for KS; HR = 5.28 [95% CI = 2.17-12.83] for NHL). Conclusions. Low CD4/CD8 ratios and high CD8 counts despite effective cART were associated with increased KS/NHL risks respectively, especially when CD4 >= 500/mm(3).

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Caby, FabienneUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Guiguet, MargueriteUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Weiss, LaurenceUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Winston, AlanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Miro, Jose M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Konopnicki, DeborahUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Le Moing, VincentUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bonnet, FabriceUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Reiss, PeterUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Mussini, CristinaUNSPECIFIEDorcid.org/0000-0002-6615-4198UNSPECIFIED
Poizot-Martin, IsabelleUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Taylor, NinonUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Skoutelis, AthanasiosUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Meyer, LaurenceUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Goujard, CecileUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bartmeyer, BarbaraUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Boesecke, ChristophUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Antinori, AndreaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Quiros-Roldan, EugeniaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Wittkop, LindaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Frederiksen, CasperUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Castagna, AntonellaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Thurnheer, Maria ChristineUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Svedhem, VeronicaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Jose, SophieUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Costagliola, DominiqueUNSPECIFIEDorcid.org/0000-0003-0765-0869UNSPECIFIED
Mary-Krause, MurielleUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Grabar, SophieUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-607219
DOI: 10.1093/cid/ciaa1137
Journal or Publication Title: Clin. Infect. Dis.
Volume: 73
Number: 1
Page Range: S. 50 - 60
Date: 2021
Publisher: OXFORD UNIV PRESS INC
Place of Publication: CARY
ISSN: 1537-6591
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
COMBINATION ANTIRETROVIRAL THERAPY; IMMUNE ACTIVATION; AIDS; INDIVIDUALS; MARKERS; EVENTS; CANCERMultiple languages
Immunology; Infectious Diseases; MicrobiologyMultiple languages
URI: http://kups.ub.uni-koeln.de/id/eprint/60721

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